Abstract：
We aimed to compare fluid status as determined by multifrequency bioimpedance spectroscopy (MF-BIS, Xitron 4200, USA) with that determined by the isotope dilution method among a contemporary Chinese cohort. Healthy Chinese subjects (HS, n = 30) were recruited in Zhengzhou. Hemodialysis (HD, n = 49) and peritoneal dialysis (PD, n = 48) patients were screened at the First Affiliated Hospital of Zhengzhou University. Total body water (TBW) and extracellular water (ECW) were measured by deuterium (TBWD) and bromide (ECWBr) dilution, respectively, and by MF-BIS using the Moissl equation (ME). The results of MF-BIS were compared to the reference method by Pearson analysis and Bland-Altman analysis in the three groups. The accuracy of overhydration as determined by MF-BIS was analyzed by receiver operating characteristic (ROC) curves. The TBWD and TBWME values were 34.67 ± 7.31 and 35.41 ± 5.76 L, 37.30 ± 8.58 and 37.02 ± 8.10 L, and 38.61 ± 10.02 and 38.44 ± 7.59 L in the HS, HD and PD groups, respectively. The ECWBr and ECWME values were 14.88 ± 3.33 and 15.53 ± 2.39 L, 16.24 ± 5.08 and 16.90 ± 3.93 L, and 19.08 ± 6.41 and 18.23 ± 3.61 L in the HS, HD and PD groups, respectively. The mean bias between TBWD and TBWME was -0.74 L, 0.28 L, and 0.17 L in the HS, HD and PD groups, respectively. The mean bias between ECWBr and ECWME was -0.65 L, -0.66 L, and 0.85 L in the HS, HD and PD groups, respectively. Compared to the ECWBr/TBWD ratio, the area under the ROC curve (AUC) of the ECWME/TBWME ratio for the diagnosis of overhydration was 0.76 and 0.68 in the HD and PD groups, respectively. In summary, MF-BIS with ME could be used in Chinese HD and PD patients.
摘要：
我们旨在比较通过多频生物阻抗谱(MF-BIS，Xitron4200，美国），通过同位素稀释法在当代中国人群中确定。健康的中国受试者(HS，n=30）在郑州招募。血液透析（HD，n=49）和腹膜透析（PD，n=48)患者在郑州大学第一附属医院进行筛查。通过氘（TBWD）和溴化物（ECWBr）稀释来测量全身水（TBW）和细胞外水（ECW），分别,并通过MF-BIS使用Moissl方程(ME)。通过Pearson分析和Bland-Altman分析将MF-BIS的结果与参考方法进行比较。通过受试者工作特征（ROC）曲线分析了通过MF-BIS确定的过度水合的准确性。TBWD和TBWME值分别为34.67±7.31和35.41±5.76L，37.30±8.58和37.02±8.10升，HS中38.61±10.02和38.44±7.59L，HD和PD组，分别。ECWBr和ECWME值分别为14.88±3.33和15.53±2.39L,16.24±5.08和16.90±3.93L，HS为19.08±6.41和18.23±3.61L，HD和PD组，分别。TBWD和TBWME之间的平均偏差为-0.74L，0.28L,和0.17L在HS，HD和PD组，分别。ECWBr和ECWME之间的平均偏差为-0.65L，-0.66L,HS和0.85升，HD和PD组，分别。与ECWBr/TBWD比相比，在HD和PD组中，诊断过度水合的ECWME/TBWME比值的ROC曲线下面积（AUC）分别为0.76和0.68，分别。总之,MF-BIS与ME可用于中国HD和PD患者。
