Abstract：
We report a case of late-onset Schnitzler syndrome successfully treated with Janus-activated kinase (JAK) inhibitors and colchicine. Schnitzler syndrome should be considered for recurrent chronic urticaria when accompanied by fever, fatigue, rapid weight loss, and poor response to antihistamine treatment. Skin biopsy, bone marrow biopsy, and electrophoresis help confirm the diagnosis. Early diagnosis and treatment can lead to complete resolution of symptoms. Besides interleukin (IL)-1 and IL-6 inhibitors, JAK inhibitors and colchicine may be considered as other choices of treatment.
摘要：
我们报告了一例迟发性Schnitzler综合征，成功使用Janus激活激酶（JAK）抑制剂和秋水仙碱治疗。Schnitzler综合征应考虑慢性荨麻疹伴有发烧时，疲劳,快速减肥，抗组胺药治疗反应差.皮肤活检,骨髓活检,电泳有助于确诊。早期诊断和治疗可导致症状的完全缓解。除白细胞介素（IL）-1和IL-6抑制剂外，JAK抑制剂和秋水仙碱可被视为其他治疗选择。
