关键词: ATMP Advanced therapy medicinal product Ethics Human embryonic stem cells Parkinson’s disease hESC

Mesh : Female Humans Human Embryonic Stem Cells Parkinson Disease / therapy Embryo, Mammalian Qualitative Research

来  源:   DOI:10.1186/s12910-022-00840-6

Abstract:
Human embryonic stem cells (hESC) as a source for the development of advanced therapy medicinal products are considered for treatment of Parkinson\'s disease (PD). Research has shown promising results and opened an avenue of great importance for patients who currently lack a disease modifying therapy. The use of hESC has given rise to moral concerns and been the focus of often heated debates on the moral status of human embryos. Approval for marketing is still pending.
To Investigate the perspectives and concerns of patients with PD, patients being the directly concerned stakeholders in the ethical discussion.
Qualitative semi-structured interviews related to this new therapy in seventeen patients from two Swedish cities.
The participants expressed various interests related to the use of human embryos for development of medicinal therapies; however, overall, they were positive towards the use of hESC for treatment of PD. It was deemed important that the donating woman or couple made the choice to donate embryos voluntarily. Furthermore, there were concerns that the industry does not always prioritise the patient over profit; thus, transparency was seen as important.
摘要:
人类胚胎干细胞(hESC)作为开发先进治疗药物的来源被认为是治疗帕金森病(PD)的药物。研究显示了有希望的结果,并为目前缺乏疾病改善疗法的患者开辟了一条非常重要的途径。hESC的使用引起了道德方面的关注,并且是关于人类胚胎道德地位的经常激烈辩论的焦点。营销审批仍在等待中。
调查PD患者的观点和关注点,患者是伦理讨论中直接相关的利益相关者。
对来自两个瑞典城市的17名患者进行了与这种新疗法相关的定性半结构化访谈。
参与者表达了与使用人类胚胎开发药物疗法有关的各种兴趣;然而,总的来说,他们对使用hESC治疗PD持积极态度.重要的是,捐赠妇女或夫妇选择自愿捐赠胚胎。此外,有人担心,该行业并不总是将患者置于利润之上;因此,透明度被认为很重要。
公众号