Abstract：
This study aimed to determine the incidence and clinicopathological patterns of metastatic carcinoma of the parotid gland.
Ninety patients with parotid gland metastases admitted to our hospital between January 2003 and December 2018 were included in this study. Clinical and pathological data were obtained from the medical records and follow-ups. Kaplan-Meier analysis was used to assess overall survival of patients.
Among the 90 patients, parotid gland metastases originated from the head and neck in 86 (95.6%), from non-head and neck in 4 (4.4%), from the oral cavity in 30(33.3%), and from the eyelid in 21 (23.3%). Among the 85 cases with parotid gland lymph node metastasis, 45 (52.9%) were diagnosed with extra-lymph node metastasis. The capsule of the parotid lymph nodes was thinner than that of the cervical lymph nodes (P < 0.05). Hematogenous metastases to the parotid gland (only five cases) were rare, mainly from the non-head and neck malignancies. Patients with oral squamous cell carcinoma and meibomian adenocarcinoma with parotid metastatic disease had poorer overall survival (P < 0.05).
Eastern China population analysis showed that parotid gland metastases usually arise from oral squamous cell carcinoma and eyelid, but rarely from cutaneous squamous cell carcinoma. Most cases metastasize to the parotid lymph nodes via the lymphatic system and are prone to extranodal extension with little or no facial nerve involvement. These findings have important implications for the treatment of metastatic parotid malignancies.
Ninety patients with parotid gland metastases admitted to our hospital between January 2003 and December 2018 were included in this study. Clinical and pathological data were obtained from the medical records and follow-ups. Kaplan-Meier analysis was used to assess overall survival of patients.
Among the 90 patients, parotid gland metastases originated from the head and neck in 86 (95.6%), from non-head and neck in 4 (4.4%), from the oral cavity in 30(33.3%), and from the eyelid in 21 (23.3%). Among the 85 cases with parotid gland lymph node metastasis, 45 (52.9%) were diagnosed with extra-lymph node metastasis. The capsule of the parotid lymph nodes was thinner than that of the cervical lymph nodes (P < 0.05). Hematogenous metastases to the parotid gland (only five cases) were rare, mainly from the non-head and neck malignancies. Patients with oral squamous cell carcinoma and meibomian adenocarcinoma with parotid metastatic disease had poorer overall survival (P < 0.05).
Eastern China population analysis showed that parotid gland metastases usually arise from oral squamous cell carcinoma and eyelid, but rarely from cutaneous squamous cell carcinoma. Most cases metastasize to the parotid lymph nodes via the lymphatic system and are prone to extranodal extension with little or no facial nerve involvement. These findings have important implications for the treatment of metastatic parotid malignancies.
摘要：
目的：本研究旨在确定腮腺转移癌的发病率和临床病理特征。
方法：纳入我院2003年1月至2018年12月收治的90例腮腺转移患者。从病历和随访中获得临床和病理数据。Kaplan-Meier分析用于评估患者的总生存期。
结果：在90例患者中，86例（95.6%）腮腺转移起源于头颈部，来自非头部和颈部的4（4.4%），来自口腔的30（33.3％），和从眼睑21（23.3％）。85例腮腺淋巴结转移患者中,45例（52.9%）诊断为淋巴结外转移。腮腺淋巴结包膜较颈淋巴结薄(P<0.05)。腮腺的血源性转移（仅5例）很少见，主要来自非头颈部恶性肿瘤。口腔鳞状细胞癌和睑板腺癌伴腮腺转移性疾病患者总生存期较差(P<0.05)。
结论：华东地区人群分析显示，腮腺转移通常来自口腔鳞状细胞癌和眼睑，但很少来自皮肤鳞状细胞癌。大多数病例通过淋巴系统转移到腮腺淋巴结，容易发生结外延伸，很少或没有面神经受累。这些发现对转移性腮腺恶性肿瘤的治疗具有重要意义。
方法：纳入我院2003年1月至2018年12月收治的90例腮腺转移患者。从病历和随访中获得临床和病理数据。Kaplan-Meier分析用于评估患者的总生存期。
结果：在90例患者中，86例（95.6%）腮腺转移起源于头颈部，来自非头部和颈部的4（4.4%），来自口腔的30（33.3％），和从眼睑21（23.3％）。85例腮腺淋巴结转移患者中,45例（52.9%）诊断为淋巴结外转移。腮腺淋巴结包膜较颈淋巴结薄(P<0.05)。腮腺的血源性转移（仅5例）很少见，主要来自非头颈部恶性肿瘤。口腔鳞状细胞癌和睑板腺癌伴腮腺转移性疾病患者总生存期较差(P<0.05)。
结论：华东地区人群分析显示，腮腺转移通常来自口腔鳞状细胞癌和眼睑，但很少来自皮肤鳞状细胞癌。大多数病例通过淋巴系统转移到腮腺淋巴结，容易发生结外延伸，很少或没有面神经受累。这些发现对转移性腮腺恶性肿瘤的治疗具有重要意义。
