PDF(Pubmed)
Abstract：
Rationale: A growing body of evidence suggests that sleep is critical for the adaptive processing and consolidation of emotional information into long-term memory. Previous research has indicated that emotional components of scenes particularly benefit from sleep in healthy groups, yet sleep-dependent emotional memory processes remain unexplored in clinical cohorts, including those with obstructive sleep apnea (OSA). This line of research is important as it will add to the understanding of how disrupted sleep in OSA contributes to both impaired cognition and emotion dysregulation. Objectives: To test the hypothesis that individuals with OSA will have impaired sleep-dependent memory consolidation, with the greatest impact being on memory for emotional content. Methods: In this study, a group of newly diagnosed patients with OSA (n = 26; 10 female; average age, 42.5 years) and a matched group of healthy control subjects (n = 24; 13 female; average age, 37 years) were enrolled in the study at Beth Israel Deaconess Medical Center. Participants encoded scenes with negative or neutral foreground objects placed on neutral backgrounds before a night of polysomnographically recorded sleep. In the morning, they completed a recognition test in which old and new scene objects and backgrounds, presented separately and one at a time, were judged as old, new, or similar compared with what had been previously viewed. Results: Patients with OSA had a deficit in recognition memory for the scenes. Overall recognition (the ability to recognize old items as either old or similar) was impaired across all scene elements, both negative and neutral objects and backgrounds, whereas specific recognition (correctly identifying old items as old) was impaired only for negative objects. Across all participants, successful overall recognition correlated positively with sleep efficiency and rapid eye movement (REM) sleep, whereas successful specific memory recognition correlated only with REM sleep. Conclusions: Our findings indicate that fragmented sleep and reduced REM sleep, both hallmarks of OSA, are associated with disruptions in general memory impairment and veridical memory for emotional content, which could alter emotional regulation and contribute to comorbid emotional distress in OSA.
摘要：
理由：越来越多的证据表明，睡眠对于情感信息的适应性处理和长期记忆的巩固至关重要。先前的研究表明，场景的情绪成分尤其受益于健康人群的睡眠，然而，依赖睡眠的情绪记忆过程仍未在临床队列中探索，包括阻塞性睡眠呼吸暂停（OSA）患者。这项研究很重要，因为它将增加对OSA睡眠中断如何导致认知和情绪失调的理解。目的：检验OSA患者睡眠依赖性记忆巩固受损的假设，对情感内容的记忆影响最大。方法:在本研究中,一组新诊断的OSA患者（n=26；10名女性；平均年龄，42.5岁）和一个匹配的健康对照组（n=24；13名女性；平均年龄，37年）参加了贝斯以色列女执事医疗中心的研究。参与者在多导睡眠记录睡眠的夜晚之前，用放置在中性背景上的负面或中性前景对象对场景进行编码。早上,他们完成了一个识别测试，其中新旧场景对象和背景，单独呈现，一次一个，被认为是老的，新,或者与以前看到的类似。结果：OSA患者对场景的识别记忆不足。所有场景元素的整体识别（将旧项目识别为旧项目或类似项目的能力）都受到损害，消极和中性的对象和背景，而特定识别(正确地将旧物品识别为旧物品)仅对负面物体受损。在所有参与者中，成功的整体识别与睡眠效率和快速眼动（REM）睡眠呈正相关，而成功的特异性记忆识别仅与REM睡眠相关。结论：我们的研究结果表明，睡眠片段化和REM睡眠减少，OSA的两个标志,与一般记忆障碍和情感内容的真实记忆中断有关，这可能会改变OSA中的情绪调节并导致并发情绪困扰。
