Development of new tools to study membrane-anchored mammalian Atg8 proteins.

研究膜锚定哺乳动物 Atg8 蛋白的新工具的开发。

• 影响指数: 13.391
• 发表时间: 05 2023 17
• 来源期刊: Autophagy
• DOI: 10.1080/15548627.2022.2132040
• PMID: 36250672
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 生物
• 作者列表: Park SW,Jeon P,Yamasaki A,Lee HE,Choi H,Mun JY,Jun YW,Park JH,Lee SH,Lee SK,Lee YK,Song HK,Lazarou M,Cho DH,Komatsu M,Noda NN,Jang DJ,Lee JA

关键词: Autophagy; GABARAP; LIR motif; RavZ protein; mammalian ATG8; selective mATG8–PE delipidation

Mesh: Animals; Autophagy-Related Protein 8 Family / metabolism; Membrane Proteins / metabolism; Sequestosome-1 Protein / metabolism; Autophagy / genetics; Apoptosis Regulatory Proteins / metabolism; Microtubule-Associated Proteins / metabolism; Mammals / metabolism

Abstract

A:C autophagic membrane:cytosol; ALS amyotrophic lateral sclerosis; ATG4 autophagy related 4; Atg8 autophagy related 8; BafA1 bafilomycin A1; BNIP3L/Nix BCL2 interacting protein 3 like; CALCOCO2/NDP52 calcium binding and coiled-coil domain 2; EBSS Earle\'s balanced salt solution; GABARAP GABA type A receptor-associated protein; GST glutathione S transferase; HKO hexa knockout; Kd dissociation constant; LIR LC3-interacting region; MAP1LC3/LC3 microtubule associated protein 1 light chain 3; NLS nuclear localization signal/sequence; PE phosphatidylethanolamine; SpHfl1 Schizosaccharomyces pombeorganic solute transmembrane transporter; SQSTM1/p62 SQSTM1/p62; TARDBP/TDP-43 TAR DNA binding protein; TKO triple knockout.

摘要

UNASSIGNED:A:C自噬膜:胞质溶胶;ALS肌萎缩侧索硬化;ATG4自噬相关4;Atg8自噬相关8;BafA1bafilomycinA1;BNIP3L/NixBCL2相互作用蛋白3样;CALCOSIGN/NDP52TAPT-TAPT-TAPT-T-T