PDF(Pubmed)
Abstract：
UNASSIGNED: Phacoemulsification is an effective and widely performed technique in cataract surgery, but the comparative anatomical outcomes, including endothelial cell loss (ECL), central corneal thickness (CCT), and central macular thickness (CMT), between high-flow and low-flow phacoemulsification cataract surgery remain unclear.
UNASSIGNED: This study followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. Random-effects models were applied to measure pooled mean differences (MD) with 95% confidence intervals (CI) of anatomical outcomes between high-flow and low-flow phacoemulsification cataract surgery. We judged overall certainty of evidence (CoE) based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria.
UNASSIGNED: We included six randomized controlled trials (RCTs) totaling 477 participants. The meta-analysis showed similar changes associated with these two surgery types in both ECL at postoperative days 2-14 (MD: -1.63%; 95% CI: -3.73 to 0.47%; CoE: very low), days 15-42 (MD: -0.65%; 95% CI -2.96 to 1.65%; CoE: very low) and day 43 to month 18 (MD: -0.35%; 95% CI: -1.48 to 0.78%; CoE: very low), and CCT at postoperative day 1 (MD: -16.37 μm; 95% CI: -56.91 to 24.17 μm; CoE: very low), days 2-14 (MD: -10.92 μm; 95% CI: -30.00 to 8.16 μm; CoE: very low) and days 15-42 (MD: -2.76 μm; 95% CI: -5.75 to 0.24 μm; CoE: low). By contrast, low-flow phacoemulsification showed less increase in CMT at postoperative days 15-42 (MD, -4.58 μm; 95% CI: -6.3 to -2.86 μm; CoE: low).
UNASSIGNED: We found similar anatomical outcomes, except in CMT, for both high-flow and low-flow phacoemulsification cataract surgery. Future head-to-head RCTs on visual outcomes should confirm our findings.
UNASSIGNED: PROSPERO, identifier: CRD42022297036.
UNASSIGNED: This study followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. Random-effects models were applied to measure pooled mean differences (MD) with 95% confidence intervals (CI) of anatomical outcomes between high-flow and low-flow phacoemulsification cataract surgery. We judged overall certainty of evidence (CoE) based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria.
UNASSIGNED: We included six randomized controlled trials (RCTs) totaling 477 participants. The meta-analysis showed similar changes associated with these two surgery types in both ECL at postoperative days 2-14 (MD: -1.63%; 95% CI: -3.73 to 0.47%; CoE: very low), days 15-42 (MD: -0.65%; 95% CI -2.96 to 1.65%; CoE: very low) and day 43 to month 18 (MD: -0.35%; 95% CI: -1.48 to 0.78%; CoE: very low), and CCT at postoperative day 1 (MD: -16.37 μm; 95% CI: -56.91 to 24.17 μm; CoE: very low), days 2-14 (MD: -10.92 μm; 95% CI: -30.00 to 8.16 μm; CoE: very low) and days 15-42 (MD: -2.76 μm; 95% CI: -5.75 to 0.24 μm; CoE: low). By contrast, low-flow phacoemulsification showed less increase in CMT at postoperative days 15-42 (MD, -4.58 μm; 95% CI: -6.3 to -2.86 μm; CoE: low).
UNASSIGNED: We found similar anatomical outcomes, except in CMT, for both high-flow and low-flow phacoemulsification cataract surgery. Future head-to-head RCTs on visual outcomes should confirm our findings.
UNASSIGNED: PROSPERO, identifier: CRD42022297036.
摘要：
未经证实：白内障超声乳化术是一种有效且广泛的白内障手术技术，但是比较的解剖学结果，包括内皮细胞损失（ECL），中央角膜厚度(CCT),和中央黄斑厚度（CMT），高流量和低流量白内障超声乳化手术之间仍不清楚。
UNASSIGNED：本研究遵循系统评价和荟萃分析（PRISMA）声明的首选报告项目。随机效应模型用于测量高流量和低流量超声乳化白内障手术之间的解剖结果的合并平均差异（MD）和95％置信区间（CI）。我们根据建议评估的等级来判断证据的总体确定性(CoE)，开发和评估（等级）标准。
UNASSIGNED：我们纳入了6项随机对照试验（RCT），共477名参与者。荟萃分析显示，在术后第2-14天，两种ECL中与这两种手术类型相关的变化相似（MD：-1.63％；95％CI：-3.73至0.47％；CoE：非常低），第15-42天（MD：-0.65％；95％CI-2.96至1.65％；CoE：非常低）和第43天至第18个月（MD：-0.35％；95％CI：-1.48至0.78％；CoE：非常低），术后第1天的CCT（MD：-16.37μm；95％CI：-56.91至24.17μm；CoE：非常低），第2-14天(MD:-10.92μm;95%CI:-30.00至8.16μm;CoE:非常低)和第15-42天(MD:-2.76μm;95%CI:-5.75至0.24μm;CoE:低)。相比之下,低流量超声乳化术在术后第15-42天显示CMT增加较少（MD，-4.58μm；95%CI：-6.3至-2.86μm；CoE：低）。
未经证实：我们发现相似的解剖结果，除了在CMT,用于高流量和低流量白内障超声乳化手术。未来关于视觉结果的头对头RCT应该证实我们的发现。
未经批准：PROSPERO，标识符：CRD42022297036。
UNASSIGNED：本研究遵循系统评价和荟萃分析（PRISMA）声明的首选报告项目。随机效应模型用于测量高流量和低流量超声乳化白内障手术之间的解剖结果的合并平均差异（MD）和95％置信区间（CI）。我们根据建议评估的等级来判断证据的总体确定性(CoE)，开发和评估（等级）标准。
UNASSIGNED：我们纳入了6项随机对照试验（RCT），共477名参与者。荟萃分析显示，在术后第2-14天，两种ECL中与这两种手术类型相关的变化相似（MD：-1.63％；95％CI：-3.73至0.47％；CoE：非常低），第15-42天（MD：-0.65％；95％CI-2.96至1.65％；CoE：非常低）和第43天至第18个月（MD：-0.35％；95％CI：-1.48至0.78％；CoE：非常低），术后第1天的CCT（MD：-16.37μm；95％CI：-56.91至24.17μm；CoE：非常低），第2-14天(MD:-10.92μm;95%CI:-30.00至8.16μm;CoE:非常低)和第15-42天(MD:-2.76μm;95%CI:-5.75至0.24μm;CoE:低)。相比之下,低流量超声乳化术在术后第15-42天显示CMT增加较少（MD，-4.58μm；95%CI：-6.3至-2.86μm；CoE：低）。
未经证实：我们发现相似的解剖结果，除了在CMT,用于高流量和低流量白内障超声乳化手术。未来关于视觉结果的头对头RCT应该证实我们的发现。
未经批准：PROSPERO，标识符：CRD42022297036。
