PDF(Pubmed)
Abstract：
Pancreatic adenocarcinoma (PAAD) is one of the most aggressive digestive system tumors in the world, with a low early diagnosis rate and a high mortality. Integrin beta 5 (ITGB5) is demonstrated to be a potent tumor promoter in several carcinomas. However, it is unknown whether ITGB5 participates in the occurrence and development of PAAD. In this study, we confirmed a high expression of ITGB5 in PAAD and its role in promoting invasiveness and transitivity in PAAD. Besides, the knockdown of ITGB5 increased cell sensitivity to radiation by promoting DNA damage repair and the MEK/ERK signaling pathway. Collectively, these results show that ITGB5 plays an essential role in pancreatic cancer growth and survival.
摘要：
胰腺腺癌(PAAD)是世界上侵袭性最强的消化系统肿瘤之一。早期诊断率低，死亡率高。整合素β5（ITGB5）被证明是几种癌症中有效的肿瘤启动子。然而,目前尚不清楚ITGB5是否参与PAAD的发生和发展。在这项研究中,我们证实了ITGB5在PAAD中的高表达及其在促进PAAD的侵袭性和传递性中的作用。此外,ITGB5的敲除通过促进DNA损伤修复和MEK/ERK信号通路增加细胞对放射的敏感性。总的来说，这些结果表明,ITGB5在胰腺癌的生长和生存中起着至关重要的作用.
