Abstract：
As the worldwide population progresses in age, there is an increasing need for effective treatments for age-associated musculoskeletal conditions such as osteoporosis and osteoarthritis (OA). Fisetin, a natural flavonoid, has garnered attention as a promising pharmaceutical option for treating or delaying the progression of osteoporosis and OA. However, there is no systematic review of the effects of fisetin on bone and cartilage. The aim of this review is to report the latest evidence on the effects of fisetin on bone and cartilage, with a focus on clinical significance. The PubMed, Embase, and Cochrane Library databases were searched up to December 9th 2021 to evaluate the effects of fisetin on bone and cartilage in in vitro studies and in vivo preclinical animal studies. The risk of bias, quality, study design, sample characteristics, dose and duration of fisetin treatment, and outcomes of the 13 eligible studies were analyzed in this systematic review. Qualitative evaluation was conducted for each study due to differences in animal species, cell type, created disease model, dose and duration of fisetin treatment, and time between intervention and assessment among the eligible studies. The beneficial effects of fisetin on osteoporosis have been demonstrated in in vitro and in vivo preclinical studies across animal species. Similarly, the beneficial effects of fisetin on OA have been demonstrated in in vivo preclinical animal studies, but the reports on OA are still limited. Fisetin, a natural supplement can be use in orthobiologics treatment, as adjuvant to orthopaedic surgery, to improve clinical outcome.
摘要：
随着世界人口年龄的增长，越来越需要有效治疗与年龄相关的肌肉骨骼疾病,如骨质疏松症和骨关节炎(OA)。Fisetin,一种天然类黄酮,作为治疗或延缓骨质疏松症和OA进展的有希望的药物选择，已经引起了人们的注意。然而,目前尚无关于非塞素对骨骼和软骨的影响的系统评价。这篇综述的目的是报告关于非塞素对骨和软骨影响的最新证据，注重临床意义。PubMed,Embase,在2021年12月9日之前，搜索了Cochrane图书馆数据库，以评估非塞素在体外研究和体内临床前动物研究中对骨骼和软骨的影响。偏见的风险，质量,研究设计，样本特征，非塞素治疗的剂量和持续时间，本系统综述分析了13项符合条件的研究的结局.由于动物种类的差异，对每项研究进行了定性评估，细胞类型,创建疾病模型，非塞素治疗的剂量和持续时间，以及符合条件的研究中干预和评估之间的时间。已经在动物物种的体外和体内临床前研究中证明了非塞素对骨质疏松症的有益作用。同样，非塞素对OA的有益作用已在体内临床前动物研究中得到证实，但是关于OA的报道仍然有限。Fisetin,天然补充剂可用于直系生物学治疗，作为骨科手术的辅助手段，改善临床结果。
