Abstract：
OBJECTIVE: To report 15 years of experience with metabolic tumor volume (MTV) of liver metastases from the preoperative 18F-FDG PET/CT to predict long-term survival after liver transplantation (LT) for unresectable colorectal liver metastases (CRLM).
METHODS: The preoperative 18F-FDG PET/CT from all SECA 1 and 2 patients was evaluated. MTV was obtained from all liver metastases. The patients were divided into one group with low MTV (< 70 cm3) and one group with high MTV (> 70 cm3) based on a receiver operating characteristic analysis. Overall survival (OS), disease-free survival (DFS) and post recurrence survival (PRS) for patients with low versus high MTV were compared using the Kaplan-Meier method and log rank test. Clinopathological features between the two groups were compared by a nonparametric Mann-Whitney U test for continuous and Fishers exact test for categorical data.
RESULTS: At total of 40 patients were included. Patients with low MTV had significantly longer OS (p < 0.001), DFS (p < 0.001) and PRS (p = 0.006) compared to patients with high values. The patients with high MTV had higher CEA levels, number of liver metastases, size of the largest liver metastasis, N-stage, number of chemotherapy lines and more frequently progression of disease at LT compared to the patients with low MTV.
CONCLUSIONS: MTV of liver metastases is highly predictive of long-term OS, DFS and PRS after LT for unresectable CRLM and should be implemented in risk stratification prior to LT.
METHODS: The preoperative 18F-FDG PET/CT from all SECA 1 and 2 patients was evaluated. MTV was obtained from all liver metastases. The patients were divided into one group with low MTV (< 70 cm3) and one group with high MTV (> 70 cm3) based on a receiver operating characteristic analysis. Overall survival (OS), disease-free survival (DFS) and post recurrence survival (PRS) for patients with low versus high MTV were compared using the Kaplan-Meier method and log rank test. Clinopathological features between the two groups were compared by a nonparametric Mann-Whitney U test for continuous and Fishers exact test for categorical data.
RESULTS: At total of 40 patients were included. Patients with low MTV had significantly longer OS (p < 0.001), DFS (p < 0.001) and PRS (p = 0.006) compared to patients with high values. The patients with high MTV had higher CEA levels, number of liver metastases, size of the largest liver metastasis, N-stage, number of chemotherapy lines and more frequently progression of disease at LT compared to the patients with low MTV.
CONCLUSIONS: MTV of liver metastases is highly predictive of long-term OS, DFS and PRS after LT for unresectable CRLM and should be implemented in risk stratification prior to LT.
摘要：
目的：报告通过术前18F-FDGPET/CT评估肝转移瘤代谢性肿瘤体积（MTV）15年的经验，以预测不可切除的结直肠癌肝转移（CRLM）肝移植（LT）后的长期生存率。
方法：评估所有SECA1和2例患者的术前18F-FDGPET/CT。MTV来自所有肝转移。根据受试者工作特征分析，将患者分为一组MTV低（<70cm3）和一组MTV高（>70cm3）。总生存期（OS），使用Kaplan-Meier方法和对数秩检验比较了低和高MTV患者的无病生存期(DFS)和复发后生存期(PRS).通过非参数Mann-WhitneyU检验对连续数据和Fishers精确检验对两组之间的临床病理学特征进行了比较。
结果：共纳入40例患者。低MTV患者的OS显著延长（p<0.001），DFS(p<0.001)和PRS(p=0.006)与患者比拟值较高。MTV高的患者有较高的CEA水平,肝转移的数量，最大肝转移的大小，N级,与低MTV患者相比，LT时化疗线路数量和疾病进展频率更高。
结论：肝转移的MTV是长期OS的高度预测，对于无法切除的CRLM，LT后的DFS和PRS应在LT前进行风险分层。
方法：评估所有SECA1和2例患者的术前18F-FDGPET/CT。MTV来自所有肝转移。根据受试者工作特征分析，将患者分为一组MTV低（<70cm3）和一组MTV高（>70cm3）。总生存期（OS），使用Kaplan-Meier方法和对数秩检验比较了低和高MTV患者的无病生存期(DFS)和复发后生存期(PRS).通过非参数Mann-WhitneyU检验对连续数据和Fishers精确检验对两组之间的临床病理学特征进行了比较。
结果：共纳入40例患者。低MTV患者的OS显著延长（p<0.001），DFS(p<0.001)和PRS(p=0.006)与患者比拟值较高。MTV高的患者有较高的CEA水平,肝转移的数量，最大肝转移的大小，N级,与低MTV患者相比，LT时化疗线路数量和疾病进展频率更高。
结论：肝转移的MTV是长期OS的高度预测，对于无法切除的CRLM，LT后的DFS和PRS应在LT前进行风险分层。
