Abstract：
To evaluate the residue levels of fluopimomide, pyraclostrobin and its metabolite BF-500-3 in garlic ecosystems, supervised garlic field trials with a commercial formulation (pyraclostrobin·fluopimomide 30% suspension concentrate (SC)) were conducted in six regions of China according to the Good Agricultural Practices (GAP). The residues of fluopimomide, pyraclostrobin and BF-500-3 in field samples were determined using a QuEChERS method combined with high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The average recoveries of all target compounds were 76-94% with relative standard deviations (RSDs) of 1.0-14.5% and limits of quantitation (LOQs) of 0.002 mg/kg. At the recommended pre-harvest interval (PHI, 10 days), the residues of fluopimomide, pyraclostrobin and BF-500-3 were below 0.16, 0.77 and 0.12 mg/kg in garlic chive; below 0.027, 0.22 and 0.002 mg/kg in garlic scape; and below 0.002, 0.002 and 0.002 mg/kg in garlic, respectively. Dietary intake risks were calculated using risk quotients (RQs) based on field residual data, toxicological data and dietary patterns. The chronic dietary risk quotients (RQc) of pyraclostrobin and fluopimomide were 48.42% and 0.36%, respectively. The acute dietary risk quotients (RQa) of pyraclostrobin in garlic were 0.06-0.15%. These results indicated a low dietary risk for consumers. This study could provide scientific guidance for the application of pyraclostrobin and fluopimomide in garlic.
摘要：
为了评估氟哌米特的残留水平，大蒜生态系统中的吡唑酮酯及其代谢产物BF-500-3，根据良好农业规范（GAP），在中国六个地区进行了商业配方（吡唑醇酯·氟哌胺30％悬浮浓缩物（SC））的监督大蒜田间试验。氟哌米特的残留物，使用QuEChERS方法结合高效液相色谱-串联质谱（HPLC-MS/MS）测定了野外样品中的吡唑酮酯和BF-500-3。所有目标化合物的平均回收率为76-94％，相对标准偏差（RSD）为1.0-14.5％，定量限（LOQs）为0.002mg/kg。在推荐的收获前间隔(PHI，10days),氟哌米特的残留物，大蒜韭菜中的吡唑酮酯和BF-500-3低于0.16、0.77和0.12mg/kg；大蒜中低于0.027、0.22和0.002mg/kg；大蒜中低于0.002、0.002和0.002mg/kg，分别。使用基于现场残差数据的风险商(RQs)计算饮食摄入风险，毒理学数据和饮食模式。吡唑酮酯和氟哌米特的慢性饮食风险商（RQc）分别为48.42％和0.36％，分别。大蒜中吡草醇酯的急性饮食风险商（RQa）为0.06-0.15％。这些结果表明消费者的饮食风险较低。本研究可为吡唑酮醇酯和氟哌米特在大蒜中的应用提供科学指导。
