Abstract：
A pandemic of respiratory disease named coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is reported prostate cancer patients are susceptible to COVID-19 infection. To understand the possible causes of prostate cancer patients\' increased vulnerability and mortality from COVID-19 infection, we focused on the two most important agents, transmembrane protease serine subtype 2 (TMPRSS2) and the C-X-C motif 10 (CXCL10). When SARS-CoV-2 binds to the host cell via S protein-angiotensin-converting enzyme-2 receptor interaction, TMPRSS2 contributes in the proteolytic cleavage of the S protein, allowing the viral and cellular membranes to fuse. CXCL10 is a cytokine found in elevated level in both COVID-19 and cancer-causing cytokine storm. We discovered that TMPRSS2 and CXCL10 are overexpressed in prostate cancer and COVID-19 using the UALCAN and GEPIA2 datasets. The functional importance of TMPRSS2 and CXCL10 in prostate cancer development was then determined by analyzing the frequency of genetic changes in their amino acid sequences using the cBioPortal online portal. Finally, we used the PANTHER database to examine the pathology of the targeted genes. We observed that TMPRSS2 and CXCL10, together with their often co-expressed genes, are important in the binding activity and immune responses in prostate cancer and COVID-19 infection, respectively. Finally, we found that TMPRSS2 and CXCL10 are two putative biomarkers responsible for the increased vulnerability and fatality of prostate cancer patients to COVID-19.
摘要：
一种名为冠状病毒病2019（COVID-19）的呼吸道疾病大流行是由一种新型冠状病毒引起的，严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）。据报道，前列腺癌患者易患COVID-19感染。了解前列腺癌患者因COVID-19感染而增加的脆弱性和死亡率的可能原因，我们专注于两个最重要的特工，跨膜蛋白酶丝氨酸亚型2（TMPRSS2）和C-X-C基序10（CXCL10）。当SARS-CoV-2通过S蛋白-血管紧张素转换酶-2受体相互作用与宿主细胞结合时，TMPRSS2有助于S蛋白的蛋白水解裂解，允许病毒和细胞膜融合。CXCL10是一种在COVID-19和致癌细胞因子风暴中均水平升高的细胞因子。使用UALCAN和GEPIA2数据集，我们发现TMPRSS2和CXCL10在前列腺癌和COVID-19中过表达。然后通过使用cBioPortal在线门户分析其氨基酸序列中的遗传变化频率来确定TMPRSS2和CXCL10在前列腺癌发展中的功能重要性。最后,我们使用PANTHER数据库检查了目标基因的病理学.我们观察到TMPRSS2和CXCL10，以及它们经常共表达的基因，在前列腺癌和COVID-19感染的结合活性和免疫反应中很重要，分别。最后,我们发现TMPRSS2和CXCL10是导致前列腺癌患者对COVID-19的脆弱性和病死率增加的两个推定的生物标志物.
