Abstract：
UNASSIGNED: This study is aimed to investigate the analgesic effect of combined dexmedetomidine and thoracic paravertebral nerve block (TPVB) on gastric cancer (GC) patients undergoing open gastrectomy.
UNASSIGNED: From May 2019 to Nov 2020, a total of 80 GC patients preparing for open gastrectomy were enrolled in our hospital and were divided into the ropivacaine (RO) group and the ropivacaine + dexmedetomidine (RD) group ad libitum. All of the patients underwent TPVB. The characteristics, usage of patient-controlled analgesia (PCA), adverse events, visual analogue scale (VAS) scores, inflammatory cytokines, and T cell subgroups between the two groups were compared.
UNASSIGNED: Patients in the RD group showed the decreased occurrence rate of postoperative adverse events and VAS scores and improved anti-inflammation and immune function. These findings implied that the application of dexmedetomidine in combination with RO in TPVB has a good postoperative analgesic effect, as well as anti-inflammatory and immune-enhancing effects.
UNASSIGNED: Dexmedetomidine as an adjunct analgesic may be potentially applied in clinical practice for GC patients undergoing open gastrectomy.
UNASSIGNED: From May 2019 to Nov 2020, a total of 80 GC patients preparing for open gastrectomy were enrolled in our hospital and were divided into the ropivacaine (RO) group and the ropivacaine + dexmedetomidine (RD) group ad libitum. All of the patients underwent TPVB. The characteristics, usage of patient-controlled analgesia (PCA), adverse events, visual analogue scale (VAS) scores, inflammatory cytokines, and T cell subgroups between the two groups were compared.
UNASSIGNED: Patients in the RD group showed the decreased occurrence rate of postoperative adverse events and VAS scores and improved anti-inflammation and immune function. These findings implied that the application of dexmedetomidine in combination with RO in TPVB has a good postoperative analgesic effect, as well as anti-inflammatory and immune-enhancing effects.
UNASSIGNED: Dexmedetomidine as an adjunct analgesic may be potentially applied in clinical practice for GC patients undergoing open gastrectomy.
摘要：
UNASSIGNED：本研究旨在探讨右美托咪定联合胸椎旁神经阻滞（TPVB）对胃癌（GC）患者开腹胃切除术后的镇痛效果。
UNASSIGNED：2019年5月至2020年11月，我院共纳入80例准备开腹胃切除术的GC患者，随机分为罗哌卡因（RO）组和罗哌卡因+右美托咪定（RD）组。所有患者均行TPVB。的特点,患者自控镇痛（PCA）的使用，不良事件,视觉模拟量表（VAS）评分，炎性细胞因子，比较两组间的T细胞亚群。
UNASSIGNED：RD组患者术后不良事件发生率和VAS评分降低，抗炎和免疫功能改善。提示右美托咪定联合RO在TPVB术后镇痛效果良好,以及抗炎和免疫增强作用。
UNASSIGNED：右美托咪定作为辅助镇痛剂有可能应用于接受开腹胃切除术的GC患者的临床实践。
UNASSIGNED：2019年5月至2020年11月，我院共纳入80例准备开腹胃切除术的GC患者，随机分为罗哌卡因（RO）组和罗哌卡因+右美托咪定（RD）组。所有患者均行TPVB。的特点,患者自控镇痛（PCA）的使用，不良事件,视觉模拟量表（VAS）评分，炎性细胞因子，比较两组间的T细胞亚群。
UNASSIGNED：RD组患者术后不良事件发生率和VAS评分降低，抗炎和免疫功能改善。提示右美托咪定联合RO在TPVB术后镇痛效果良好,以及抗炎和免疫增强作用。
UNASSIGNED：右美托咪定作为辅助镇痛剂有可能应用于接受开腹胃切除术的GC患者的临床实践。
