Abstract：
The Kidney Disease Improving Global Outcomes (KDIGO) guidelines are currently used in acute kidney injury (AKI) diagnosis and include both serum creatinine (SCR) and urine output (UO) criteria. Currently, many AKI-related studies have inconsistently defined AKI, which possibly affects the comparison of their results. Therefore, we hypothesized that the different criteria in the KDIGO guidelines vary in measuring the incidence of AKI and its association with clinical outcomes. We retrospectively analyzed that data of patients admitted to the intensive care unit after non-cardiac surgery in 2019. Three different criteria used to define AKI were included: UOmean, mean UO < 0.5 mL/kg/h over time; UOcont, hourly UO < 0.5 mL/kg/h over time; or SCR, KDIGO guidelines SCR criteria. A total of 777 patients were included, and the incidence of UOmean-AKI was 33.1%, the incidence of UOcont-AKI was 7.9%, and the incidence of SCR-AKI was 2.0%. There were differences in the length of ICU stay and hospital stay between AKI and non-AKI patients under different criteria. We found differences in the incidence and clinical outcomes of AKI after non-cardiac surgery when using different KDIGO criteria.
摘要：
肾脏疾病改善全球结果（KDIGO）指南目前用于急性肾损伤（AKI）诊断，包括血清肌酐（SCR）和尿量（UO）标准。目前,许多与AKI相关的研究对AKI的定义不一致，这可能会影响他们结果的比较。因此,我们假设KDIGO指南中的不同标准在测量AKI的发生率及其与临床结局的相关性方面存在差异.我们回顾性分析了2019年非心脏手术后入住重症监护病房的患者数据。用于定义AKI的三个不同标准包括：UOmean，随着时间的推移，平均UO<0.5mL/kg/h；UOcont，随着时间的推移，每小时UO<0.5mL/kg/h；或SCR，KDIGO准则SCR标准。共纳入777名患者，UOmean-AKI的发病率为33.1%,UOcont-AKI的发病率为7.9%，SCR-AKI的发生率为2.0%。不同标准下AKI与非AKI患者的ICU住院时间和住院时间存在差异。我们发现，当使用不同的KDIGO标准时，非心脏手术后AKI的发生率和临床结局存在差异。
