Abstract：
(1) Background: Affective distress can be triggered by aggressive stimuli with an unfavorable role for the individual. Some of the factors that lead to the development and evolution of a mental disorder can be genetic. The aim of this study is to determine some correlations between the human leukocyte antigen (HLA) genes and the affective distress profile (PDA). (2) Methods: A psychological assessment and testing tool for anxiety was applied to 115 people. The low-resolution HLA alleles of class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1 and HLA-DQB1) were identified by the PCR technique after DNA extraction from the blood. Depending on the PDA, the subjects were divided into two groups: a group with a low PDA and another one with a medium and high PDA. The IBM SPSS software was used to compare the frequency of HLA alleles between the two groups. (3) Results: The univariate analysis revealed a significant association of the HLA-A locus (A*01, A*30), HLA-B (B*08), and HLA-DRB1 (DRB1*11) with the low PDA group and of the HLA-A locus (A*32), HLA-B (B*52), and HLA-C (C*12) with the medium and high PDA group. (4) Conclusions: The present study highlighted potential associations between HLA alleles and anxiety disorders.
摘要：
（1）背景：积极的刺激可以触发情感困扰，对个体具有不利的作用。导致精神障碍发展和进化的一些因素可能是遗传的。这项研究的目的是确定人类白细胞抗原（HLA）基因与情感困扰谱（PDA）之间的某些相关性。(2)方法:应用焦虑心理测评工具对115人进行调查。I类的低分辨率HLA等位基因(HLA-A，HLA-B,从血液中提取DNA后，通过PCR技术鉴定出HLA-C）和II类（HLA-DRB1和HLA-DQB1）。取决于PDA,将受试者分为两组：一组PDA低，另一组PDA中，高。采用IBMSPSS软件比较两组HLA等位基因频率。(3)结果:单因素分析显示HLA-A位点(A*01,A*30)显著相关,HLA-B(B*08),和HLA-DRB1（DRB1*11）与低PDA组和HLA-A基因座（A*32），HLA-B（B*52），HLA-C(C*12)与中、高PDA组比较。（4）结论：本研究强调了HLA等位基因与焦虑症之间的潜在关联。
