PDF(Pubmed)
Abstract：
Aquagenic wrinkling of the palms (AWoP) is a rare dermatosis of significant psychosocial embarrassment and missed employment opportunities. It is characterized by development of translucent papules and wrinkling of the palms and rarely of soles shortly after immersion in water. Associated burning pain or pruritus of variable intensity is often distressing. The symptoms subside spontaneously 10-60 minutes after drying of hands only to recur following contact with water resulting in mild palmar hyperkeratosis over time. Although, cystic fibrosis remains the most described association, its cause is unknown in majority. The treatment is usually unsatisfactory and remains challenging. Response to antihistamines, iontophoresis, topical aluminum chloride 15-20% solution, and aluminum chloride hexahydrate 20% in anhydrous ethyl alcohol remains inconsistent. Keratolytic creams, petroleum jelly and/or use of gloves are not found useful at all. This paper describes a case of AWoP treated successfully with topical tacrolimus 0.1% ointment. We feel that topical tarolimus provides an effective and safe therapeutic option in AWoP.
摘要：
手掌的水生性皱纹（AWoP）是一种罕见的皮肤病，具有严重的心理社会尴尬和错过的就业机会。它的特征是在浸入水中后不久出现半透明丘疹和手掌起皱，很少出现鞋底。相关的灼热疼痛或不同强度的瘙痒通常令人痛苦。在干燥手后10-60分钟，症状会自行消退，仅在与水接触后复发，随着时间的推移会导致轻度的手掌角化过度。虽然,囊性纤维化仍然是描述最多的关联，它的原因在大多数情况下是未知的。治疗通常不能令人满意，并且仍然具有挑战性。抗组胺药的反应,离子电渗疗法,外用氯化铝15-20%溶液，和氯化铝六水合物20%在无水乙醇中仍然不一致。角质层松解剂,发现凡士林和/或手套的使用根本没有用处。本文介绍了应用0.1%他克莫司外用软膏成功治疗AWoP的一例。我们认为外用tarolimus在AWoP中提供了有效和安全的治疗选择。
