Abstract：
Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt signalling pathway. The Wnt/β-catenin signalling pathway is highly conserved evolutionarily, and activation or inhibition of either of the pathways may lead to cancer development and progression. The aim of this review is to analyse the mechanisms of action of related molecules in the Wnt/β-catenin pathway in haematologic malignancies and their feasibility as therapeutic targets.
摘要：
白血病和淋巴瘤是常见的恶性肿瘤。Wnt通路是调节细胞增殖和分化的蛋白质的复杂网络,以及癌症的发展，分为Wnt/β-连环蛋白信号通路(经典Wnt信号通路)和非经典Wnt信号通路。Wnt/β-catenin信号通路在进化上是高度保守的,和激活或抑制任一途径可能导致癌症的发展和进展。这篇综述的目的是分析Wnt/β-catenin通路中相关分子在血液恶性肿瘤中的作用机制及其作为治疗靶点的可行性。
