Mesh : Action Potentials Hippocampus Humans Memory

来  源:   DOI:10.1038/s41467-022-33536-x   PDF(Pubmed)

Abstract:
Decades of rodent research have established the role of hippocampal sharp wave ripples (SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings in humans have suggested their role in episodic and semantic memory. Yet, common standards for recording, detection, and reporting do not exist. Here, we outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations. We argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.
摘要:
数十年的啮齿动物研究已经确立了海马锐波涟漪(SPW-Rs)在巩固和指导经验中的作用。最近,人类的颅内记录表明了它们在情景记忆和语义记忆中的作用。然而,记录的通用标准,检测,报告不存在。这里,我们概述了检测纹波事件所涉及的方法学挑战,并提供了改善与其他高频振荡分离的实用建议。我们认为共享实验,检测,报告标准将为未来的转化发现提供坚实的基础。
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