Abstract：
Background Diosgenin, extracted from Dioscorea esculenta, has been reported to decrease prostaglandin E2 (PGE2) levels and any other inflammatory cytokine in rodents. However, it is still unclear whether D. esculenta intake suppressed PGE2 production and menstrual pain and premenstrual syndrome (PMS) in younger female. Aim This study aims to investigate the effect of D. esculenta intake on PGE2 and cytochrome c oxidase subunit 2 (COX-2) levels and on menstrual pain and PMS in young women. This is a randomized, double-blind, placebo-controlled, crossover study. Methods Ten healthy young females were administered either a placebo or D. esculenta (300 mg/day) for 4 weeks, followed by a 4-week washout period. Fasting blood sample was taken from the fingertips on the second day of menstrual cycle began and obtained 24h before the last D. esculenta to avoid acute effects. Participants then switched treatments for 4 weeks as a second trial. Plasma PGE2 and COX-2 levels were measured before and after each trial. The visual analogue scale (VAS), McGill pain questionnaire (MPQ), and Daily Record of Severity of Problems (DRSP) were also evaluated. The study was set and conducted from 2019 to 2020. Results PGE2 and COX-2 levels significantly decreased after D. esculenta intake compared to placebo (p = 0.038, p = 0.042 each). The VAS and DRSP scores were also significantly lower after D. esculenta intake (p = 0.046, p = 0.035 each). Conclusion Four-week D. esculenta intake suppressed PGE2 and COX-2 levels resulting in an improvement in PMS symptoms and menstrual pain in young women.
摘要：
背景皂苷元,从山药中提取，据报道，在啮齿类动物中，前列腺素E2（PGE2）水平和任何其他炎性细胞因子都会降低。然而,目前尚不清楚D.esculenta的摄入是否抑制了年轻女性的PGE2产生以及月经疼痛和经前期综合征(PMS).目的本研究旨在研究D.esculenta摄入对年轻女性PGE2和细胞色素C氧化酶亚基2（COX-2）水平以及对月经疼痛和PMS的影响。这是一个随机的，双盲,安慰剂对照,交叉研究。方法10例健康年轻女性服用安慰剂或D.esculenta（300mg/d），持续4周。接下来是4周的冲洗期。在月经周期开始的第二天从指尖采集空腹血样，并在最后一次D.esculenta之前24小时获得，以避免急性影响。参与者随后切换治疗4周作为第二次试验。在每次试验之前和之后测量血浆PGE2和COX-2水平。视觉模拟量表(VAS)麦吉尔疼痛问卷（MPQ），还评估了每日问题严重程度记录(DRSP)。该研究于2019年至2020年进行。结果与安慰剂相比，服用D.esculenta后PGE2和COX-2水平显着降低（p=0.038，p=0.042）。摄入D.esculenta后，VAS和DRSP评分也显着降低（p=0.046，p=0.035）。结论4周服用esculenta抑制了年轻女性的PGE2和COX-2水平，从而改善了PMS症状和月经疼痛。
