PDF(Pubmed)
Abstract：
UNASSIGNED: Post-vasectomy pain syndrome (PVPS) is difficult to treat. Direct damage to the vas deferens, inflammation, compression of nerves through fibrotic adhesions, and congestion of the epididymis are known to cause PVPS. The purpose of this study was to evaluate whether the application of anti-adhesion agents after vasectomy can reduce the degree of adhesion and fibrosis in a rat model.
UNASSIGNED: In the study, 11 Sprague-Dawley rats (22 vas deferens) from each group were evaluated. In the experimental group, surgery was terminated after applying the anti-adhesion agent; this was not applied in the control group. After 14 days of vasectomy, the scrotum was dissected to evaluate the degree of gross adhesion at the vasectomy site. Histological examination of the surrounding tissues, including the vas deferens and the spermatic cord, was also performed.
UNASSIGNED: Adhesions were not observed in 72.73% (16/22) rats from the experimental group, in which the anti-adhesion agent was applied; in contrast, the incidence of adhesions in the control group was 100%. There was a statistically significant relationship between the distribution of grades for adhesion and anti-adhesion agent (chi-square, P<0.001). On classification of fibrosis and inflammation, application of the anti-adhesion agent was significantly associated with lower grade inflammation and fibrosis compared to that of the control group (chi-square, P=0.001). The rate of intact muscle structure was 90.91% (20/22) in the experimental group, and 36.36% (8/22) in the control group, and the application of the anti-adhesion agent demonstrated significant association with preservation of intact muscle structure (chi-square, P<0.001).
UNASSIGNED: The application of an anti-adhesion agent after vasectomy prevented the development of adhesion, fibrosis, and inflammation reaction and further reduced structural destruction.
UNASSIGNED: In the study, 11 Sprague-Dawley rats (22 vas deferens) from each group were evaluated. In the experimental group, surgery was terminated after applying the anti-adhesion agent; this was not applied in the control group. After 14 days of vasectomy, the scrotum was dissected to evaluate the degree of gross adhesion at the vasectomy site. Histological examination of the surrounding tissues, including the vas deferens and the spermatic cord, was also performed.
UNASSIGNED: Adhesions were not observed in 72.73% (16/22) rats from the experimental group, in which the anti-adhesion agent was applied; in contrast, the incidence of adhesions in the control group was 100%. There was a statistically significant relationship between the distribution of grades for adhesion and anti-adhesion agent (chi-square, P<0.001). On classification of fibrosis and inflammation, application of the anti-adhesion agent was significantly associated with lower grade inflammation and fibrosis compared to that of the control group (chi-square, P=0.001). The rate of intact muscle structure was 90.91% (20/22) in the experimental group, and 36.36% (8/22) in the control group, and the application of the anti-adhesion agent demonstrated significant association with preservation of intact muscle structure (chi-square, P<0.001).
UNASSIGNED: The application of an anti-adhesion agent after vasectomy prevented the development of adhesion, fibrosis, and inflammation reaction and further reduced structural destruction.
摘要：
未经证实：输精管结扎后疼痛综合征（PVP）难以治疗。直接损伤输精管,炎症,通过纤维粘连压迫神经，已知附睾的充血会导致PVPS。目的评价输精管结扎术后应用抗粘连剂能否减轻大鼠模型的粘连和纤维化程度。
未经批准：在研究中，评价每组11只Sprague-Dawley大鼠(22只输精管)。在实验组中,应用抗粘连剂后终止手术;对照组未应用此方法.输精管结扎14天后,解剖阴囊以评估输精管切除术部位的大体粘连程度.周围组织的组织学检查，包括输精管和精索，也进行了。
UNASSIGNED：实验组的72.73％（16/22）大鼠未观察到粘连，其中应用了抗粘连剂；相比之下，对照组粘连发生率为100%。附着力和抗粘连剂的等级分布之间存在统计学上的显着关系（卡方，P<0.001)。关于纤维化和炎症的分类，与对照组相比，抗粘连剂的应用与较低度的炎症和纤维化显着相关（卡方，P=0.001)。实验组肌肉结构完整率为90.91%(20/22),对照组为36.36%(8/22)，并且抗粘连剂的应用表明与完整肌肉结构的保存显着相关（卡方，P<0.001)。
UNASSIGNED：输精管结扎术后应用抗粘连剂可防止粘连的发展，纤维化，和炎症反应，进一步减少结构破坏。
未经批准：在研究中，评价每组11只Sprague-Dawley大鼠(22只输精管)。在实验组中,应用抗粘连剂后终止手术;对照组未应用此方法.输精管结扎14天后,解剖阴囊以评估输精管切除术部位的大体粘连程度.周围组织的组织学检查，包括输精管和精索，也进行了。
UNASSIGNED：实验组的72.73％（16/22）大鼠未观察到粘连，其中应用了抗粘连剂；相比之下，对照组粘连发生率为100%。附着力和抗粘连剂的等级分布之间存在统计学上的显着关系（卡方，P<0.001)。关于纤维化和炎症的分类，与对照组相比，抗粘连剂的应用与较低度的炎症和纤维化显着相关（卡方，P=0.001)。实验组肌肉结构完整率为90.91%(20/22),对照组为36.36%(8/22)，并且抗粘连剂的应用表明与完整肌肉结构的保存显着相关（卡方，P<0.001)。
UNASSIGNED：输精管结扎术后应用抗粘连剂可防止粘连的发展，纤维化，和炎症反应，进一步减少结构破坏。
