PDF(Pubmed)
Abstract：
UNASSIGNED: To identify novel biomarker insulin-like growth factor binding protein-2 (IGFBP-2) associated with preeclampsia (PE) before 20 weeks of gestation and to explore the predictive value of plasma IGFBP-2 in PE.
UNASSIGNED: A prospective nested case-control investigation involving 122 PE patients and 122 normal controls (NC) that were matched 1 : 1 in terms of age and week of pregnancy was carried out in Guangzhou Women and Children\'s Medical Center (Guangzhou, China, 2018030306) from April 2016 to December 2019. At 8 to 20 weeks, blood samples from the mother were taken. To calculate the correlations, univariate conditional logistic regression was employed.
UNASSIGNED: Herein, 12 clinical indices were significantly different between the PE and NC groups (uric acid (UA), cystatin C (Cys C), aspartate aminotransferase (AST), glutamyl transpeptidase (γ-GT), total bilirubin (TB), prothrombin time (PT), red blood cell (RBC), hematocrit (HCT), red cell distribution width (RDW), platelets (PLT), mean platelet volume (MPV), and thrombocytocrit (PCT)). Compared with the NC group (36.79 ± 19.91 pg/mL), the expression level of IGFBP2 in the PE group (19.76 ± 19.40 pg/mL) before 20 weeks of pregnancy was significantly decreased (P < 0.01). Two high-risk factors were found to be significantly associated with PE independently of confounders: anemia 4.35 (2.20-8.45) (P < 0.01) and cesarean section history 8.25 (2.67-26.67) (P < 0.01). As a result of the univariate logistic regression analysis, the following three variables were included in the final logistic regression model.: Y = -18.841 - 0.085 × (IGFBP-2) + 0.630 × (RDW) + 0.165 × (AST) + 0.863 × (MPV). In comparison to IGFBP-2 alone as an independent predictor of PE (AUC = 0.897, 95% CI 0.830-0.964), the model\'s discriminatory power was considerably higher (AUC = 0.953, 95% CI 0.911-0.995).
UNASSIGNED: Plasma IGFBP-2 before 20 weeks of pregnancy combined with high-risk factors and routine blood indexes has a high early predictive value for PE.
UNASSIGNED: A prospective nested case-control investigation involving 122 PE patients and 122 normal controls (NC) that were matched 1 : 1 in terms of age and week of pregnancy was carried out in Guangzhou Women and Children\'s Medical Center (Guangzhou, China, 2018030306) from April 2016 to December 2019. At 8 to 20 weeks, blood samples from the mother were taken. To calculate the correlations, univariate conditional logistic regression was employed.
UNASSIGNED: Herein, 12 clinical indices were significantly different between the PE and NC groups (uric acid (UA), cystatin C (Cys C), aspartate aminotransferase (AST), glutamyl transpeptidase (γ-GT), total bilirubin (TB), prothrombin time (PT), red blood cell (RBC), hematocrit (HCT), red cell distribution width (RDW), platelets (PLT), mean platelet volume (MPV), and thrombocytocrit (PCT)). Compared with the NC group (36.79 ± 19.91 pg/mL), the expression level of IGFBP2 in the PE group (19.76 ± 19.40 pg/mL) before 20 weeks of pregnancy was significantly decreased (P < 0.01). Two high-risk factors were found to be significantly associated with PE independently of confounders: anemia 4.35 (2.20-8.45) (P < 0.01) and cesarean section history 8.25 (2.67-26.67) (P < 0.01). As a result of the univariate logistic regression analysis, the following three variables were included in the final logistic regression model.: Y = -18.841 - 0.085 × (IGFBP-2) + 0.630 × (RDW) + 0.165 × (AST) + 0.863 × (MPV). In comparison to IGFBP-2 alone as an independent predictor of PE (AUC = 0.897, 95% CI 0.830-0.964), the model\'s discriminatory power was considerably higher (AUC = 0.953, 95% CI 0.911-0.995).
UNASSIGNED: Plasma IGFBP-2 before 20 weeks of pregnancy combined with high-risk factors and routine blood indexes has a high early predictive value for PE.
摘要：
未经批准：目的在妊娠20周前鉴定与先兆子痫（PE）相关的新型生物标志物胰岛素样生长因子结合蛋白-2（IGFBP-2），并探讨血浆IGFBP-2在PE中的预测价值。
UNASSIGNED：在广州妇女和儿童医学中心（广州，中国,2018030306）从2016年4月到2019年12月。在8到20周，采集了母亲的血样。为了计算相关性，采用单因素条件逻辑回归。
未经批准：此处，12项临床指标在PE组和NC组之间有显著差异(尿酸(UA)，胱抑素C（CysC），天冬氨酸转氨酶（AST），谷氨酰转肽酶（γ-GT），总胆红素（TB），凝血酶原时间（PT），红细胞（RBC），血细胞比容(HCT),红细胞分布宽度(RDW)，血小板(PLT),平均血小板体积（MPV），和血小板抑制（PCT））。与NC组(36.79±19.91pg/mL)相比,妊娠20周前PE组IGFBP2表达水平(19.76±19.40pg/mL)明显降低(P<0.01)。发现两个独立于混杂因素的高危因素与PE显着相关：贫血4.35（2.20-8.45）（P<0.01）和剖宫产史8.25（2.67-26.67）（P<0.01）。作为单变量逻辑回归分析的结果，最终的逻辑回归模型包括以下三个变量.Y=-18.841-0.085×(IGFBP-2)+0.630×(RDW)+0.165×(AST)+0.863×(MPV)。与单独作为PE的独立预测因子的IGFBP-2相比（AUC=0.897，95％CI0.830-0.964），模型的鉴别力明显更高(AUC=0.953,95%CI0.911-0.995).
UNASSIGNED：妊娠20周前血浆IGFBP-2合并高危因素及血常规指标对PE有较高的早期预测价值。
UNASSIGNED：在广州妇女和儿童医学中心（广州，中国,2018030306）从2016年4月到2019年12月。在8到20周，采集了母亲的血样。为了计算相关性，采用单因素条件逻辑回归。
未经批准：此处，12项临床指标在PE组和NC组之间有显著差异(尿酸(UA)，胱抑素C（CysC），天冬氨酸转氨酶（AST），谷氨酰转肽酶（γ-GT），总胆红素（TB），凝血酶原时间（PT），红细胞（RBC），血细胞比容(HCT),红细胞分布宽度(RDW)，血小板(PLT),平均血小板体积（MPV），和血小板抑制（PCT））。与NC组(36.79±19.91pg/mL)相比,妊娠20周前PE组IGFBP2表达水平(19.76±19.40pg/mL)明显降低(P<0.01)。发现两个独立于混杂因素的高危因素与PE显着相关：贫血4.35（2.20-8.45）（P<0.01）和剖宫产史8.25（2.67-26.67）（P<0.01）。作为单变量逻辑回归分析的结果，最终的逻辑回归模型包括以下三个变量.Y=-18.841-0.085×(IGFBP-2)+0.630×(RDW)+0.165×(AST)+0.863×(MPV)。与单独作为PE的独立预测因子的IGFBP-2相比（AUC=0.897，95％CI0.830-0.964），模型的鉴别力明显更高(AUC=0.953,95%CI0.911-0.995).
UNASSIGNED：妊娠20周前血浆IGFBP-2合并高危因素及血常规指标对PE有较高的早期预测价值。
