PDF(Pubmed)
Abstract：
UNASSIGNED: Monoclonal gammopathy of undetermined significance (MGUS) is associated with renal dysfunction, inflammation, and increased cardiovascular mortality, but the cardiovascular risks are not fully understood.
UNASSIGNED: The authors explored the association of MGUS with a spectrum of cardiovascular diseases using the Danish nationwide databases.
UNASSIGNED: Between 1995 and 2018, patients 18 years and older with MGUS were age- and sex-matched (1:10) with control patients and followed prospectively until December 31, 2018, for the occurrence of cardiovascular diseases. Patients diagnosed with multiple myeloma, lymphoma, or amyloidosis were excluded. Multivariable adjusted hazard ratios (HRs) for cardiovascular outcomes were estimated using Cox proportional hazard regression.
UNASSIGNED: Patients with MGUS (n = 8,189; mean age 69.8 ± 11.7 years; 51.2% male) had higher prevalence of cardiovascular risk factors at baseline, including hypertension (48.0% vs 38.5%) and type 2 diabetes (13.0% vs 9.3%), compared with control patients. Outcomes included an increased risk of heart failure (HR: 1.55; 95% CI: 1.41-1.69), acute myocardial infarction (HR: 1.22; 95% CI: 1.06-1.40), ischemic stroke (HR: 1.16; 95% CI: 1.03-1.30), atrial fibrillation (HR: 1.32; 95% CI: 1.23-1.42), aortic aneurysm (HR: 1.55; 95% CI: 1.28-1.89), aortic stenosis (HR: 1.60; 95% CI: 1.41-1.82), aortic regurgitation (HR: 1.67; 95% CI: 1.34-2.07), heart block (HR: 1.32; 95% CI: 1.08-1.61), peripheral artery disease (HR: 1.69; 95% CI: 1.47-1.95), cor pulmonale (HR: 2.06; 95% CI: 1.55-2.73), and venous thromboembolism (HR: 1.43; 95% CI: 1.24-1.65). A sensitivity analysis including only patients without certain comorbidities (type 2 diabetes, hypertension, acute myocardial infarction, and chronic kidney disease) yielded similar results.
UNASSIGNED: MGUS is associated with a broad spectrum of cardiovascular diseases, with greater relative risks observed for diseases previously associated with infiltrative and inflammatory disorders. Further studies are warranted to explore the underlying mechanisms.
UNASSIGNED: The authors explored the association of MGUS with a spectrum of cardiovascular diseases using the Danish nationwide databases.
UNASSIGNED: Between 1995 and 2018, patients 18 years and older with MGUS were age- and sex-matched (1:10) with control patients and followed prospectively until December 31, 2018, for the occurrence of cardiovascular diseases. Patients diagnosed with multiple myeloma, lymphoma, or amyloidosis were excluded. Multivariable adjusted hazard ratios (HRs) for cardiovascular outcomes were estimated using Cox proportional hazard regression.
UNASSIGNED: Patients with MGUS (n = 8,189; mean age 69.8 ± 11.7 years; 51.2% male) had higher prevalence of cardiovascular risk factors at baseline, including hypertension (48.0% vs 38.5%) and type 2 diabetes (13.0% vs 9.3%), compared with control patients. Outcomes included an increased risk of heart failure (HR: 1.55; 95% CI: 1.41-1.69), acute myocardial infarction (HR: 1.22; 95% CI: 1.06-1.40), ischemic stroke (HR: 1.16; 95% CI: 1.03-1.30), atrial fibrillation (HR: 1.32; 95% CI: 1.23-1.42), aortic aneurysm (HR: 1.55; 95% CI: 1.28-1.89), aortic stenosis (HR: 1.60; 95% CI: 1.41-1.82), aortic regurgitation (HR: 1.67; 95% CI: 1.34-2.07), heart block (HR: 1.32; 95% CI: 1.08-1.61), peripheral artery disease (HR: 1.69; 95% CI: 1.47-1.95), cor pulmonale (HR: 2.06; 95% CI: 1.55-2.73), and venous thromboembolism (HR: 1.43; 95% CI: 1.24-1.65). A sensitivity analysis including only patients without certain comorbidities (type 2 diabetes, hypertension, acute myocardial infarction, and chronic kidney disease) yielded similar results.
UNASSIGNED: MGUS is associated with a broad spectrum of cardiovascular diseases, with greater relative risks observed for diseases previously associated with infiltrative and inflammatory disorders. Further studies are warranted to explore the underlying mechanisms.
摘要：
未经证实：意义不明的单克隆丙种球蛋白病（MGUS）与肾功能不全有关，炎症,和增加心血管死亡率，但心血管风险尚未完全了解。
UNASSIGNED：作者使用丹麦全国数据库探索MGUS与一系列心血管疾病的关联。
UNASSIGNED：在1995年至2018年之间，18岁及以上的MGUS患者与对照组患者的年龄和性别匹配（1：10），并前瞻性随访至2018年12月31日，以发生心血管疾病。被诊断为多发性骨髓瘤的患者，淋巴瘤或淀粉样变性被排除。使用Cox比例风险回归估计心血管结局的多变量校正风险比（HRs）。
UNASSIGNED：MGUS患者（n=8,189；平均年龄69.8±11.7岁；51.2％男性）在基线时心血管危险因素的患病率更高，包括高血压（48.0％vs38.5％）和2型糖尿病（13.0％vs9.3％），与对照组患者相比。结果包括心力衰竭风险增加（HR：1.55;95％CI：1.41-1.69），急性心肌梗死（HR：1.22；95%CI：1.06-1.40），缺血性卒中（HR：1.16；95%CI：1.03-1.30），心房颤动（HR：1.32；95%CI：1.23-1.42），主动脉瘤（HR：1.55；95%CI：1.28-1.89），主动脉瓣狭窄（HR：1.60；95%CI：1.41-1.82），主动脉瓣反流(HR:1.67;95%CI:1.34-2.07),心脏传导阻滞（HR：1.32；95%CI：1.08-1.61），外周动脉疾病（HR：1.69；95%CI：1.47-1.95），肺心病（HR：2.06；95%CI：1.55-2.73），和静脉血栓栓塞（HR：1.43;95％CI：1.24-1.65）。敏感性分析仅包括没有某些合并症的患者(2型糖尿病，高血压,急性心肌梗死,和慢性肾脏疾病）产生类似的结果。
未经批准：MGUS与广泛的心血管疾病相关，观察到以前与浸润性和炎症性疾病相关的疾病的相对风险更大。需要进一步的研究来探索潜在的机制。
UNASSIGNED：作者使用丹麦全国数据库探索MGUS与一系列心血管疾病的关联。
UNASSIGNED：在1995年至2018年之间，18岁及以上的MGUS患者与对照组患者的年龄和性别匹配（1：10），并前瞻性随访至2018年12月31日，以发生心血管疾病。被诊断为多发性骨髓瘤的患者，淋巴瘤或淀粉样变性被排除。使用Cox比例风险回归估计心血管结局的多变量校正风险比（HRs）。
UNASSIGNED：MGUS患者（n=8,189；平均年龄69.8±11.7岁；51.2％男性）在基线时心血管危险因素的患病率更高，包括高血压（48.0％vs38.5％）和2型糖尿病（13.0％vs9.3％），与对照组患者相比。结果包括心力衰竭风险增加（HR：1.55;95％CI：1.41-1.69），急性心肌梗死（HR：1.22；95%CI：1.06-1.40），缺血性卒中（HR：1.16；95%CI：1.03-1.30），心房颤动（HR：1.32；95%CI：1.23-1.42），主动脉瘤（HR：1.55；95%CI：1.28-1.89），主动脉瓣狭窄（HR：1.60；95%CI：1.41-1.82），主动脉瓣反流(HR:1.67;95%CI:1.34-2.07),心脏传导阻滞（HR：1.32；95%CI：1.08-1.61），外周动脉疾病（HR：1.69；95%CI：1.47-1.95），肺心病（HR：2.06；95%CI：1.55-2.73），和静脉血栓栓塞（HR：1.43;95％CI：1.24-1.65）。敏感性分析仅包括没有某些合并症的患者(2型糖尿病，高血压,急性心肌梗死,和慢性肾脏疾病）产生类似的结果。
未经批准：MGUS与广泛的心血管疾病相关，观察到以前与浸润性和炎症性疾病相关的疾病的相对风险更大。需要进一步的研究来探索潜在的机制。
