PDF(Pubmed)
Abstract：
UNASSIGNED: In December 2021, a large-scale epidemic broke out in Xi\'an, China, due to SARS-CoV-2 infection. This study reports the effect of vaccination on COVID-19 and evaluates the impact of different vaccine doses on routine laboratory markers.
UNASSIGNED: The laboratory data upon admission, of 231 cases with COVID-19 hospitalized from December 8, 2021 to January 20, 2022 in Xi\'an, including blood routine, lymphocyte subtypes, coagulative function tests, virus specific antibodies and blood biochemical tests were collected and analyzed.
UNASSIGNED: Of the 231 patients, 21 were not vaccinated, 158 were vaccinated with two doses and 52 with three doses. Unvaccinated patients had a higher proportion of moderate and severe symptoms than vaccinated patients, while two-dose vaccinated patients had a higher proportion than three-dose vaccinated patients. SARS-CoV-2 specific IgG levels were significantly elevated in vaccinated patients compared with unvaccinated patients. Particularly, unvaccinated patients had lower counts and percentages of lymphocytes, eosinophils and CD8+ T-lymphocytes, and elevated coagulation-related markers. In addition, vaccination had no effect on liver and kidney function.
UNASSIGNED: Vaccination against SARS-CoV-2, inducing high IgG level and increased CD8+ T cells and eosinophils, and regulating coagulation function, can significantly attenuate symptoms of COVID-19, suggesting that the vaccine remains protective against SARS-CoV-2.
UNASSIGNED: The laboratory data upon admission, of 231 cases with COVID-19 hospitalized from December 8, 2021 to January 20, 2022 in Xi\'an, including blood routine, lymphocyte subtypes, coagulative function tests, virus specific antibodies and blood biochemical tests were collected and analyzed.
UNASSIGNED: Of the 231 patients, 21 were not vaccinated, 158 were vaccinated with two doses and 52 with three doses. Unvaccinated patients had a higher proportion of moderate and severe symptoms than vaccinated patients, while two-dose vaccinated patients had a higher proportion than three-dose vaccinated patients. SARS-CoV-2 specific IgG levels were significantly elevated in vaccinated patients compared with unvaccinated patients. Particularly, unvaccinated patients had lower counts and percentages of lymphocytes, eosinophils and CD8+ T-lymphocytes, and elevated coagulation-related markers. In addition, vaccination had no effect on liver and kidney function.
UNASSIGNED: Vaccination against SARS-CoV-2, inducing high IgG level and increased CD8+ T cells and eosinophils, and regulating coagulation function, can significantly attenuate symptoms of COVID-19, suggesting that the vaccine remains protective against SARS-CoV-2.
摘要：
联合国：2021年12月，西安爆发大规模疫情，中国,由于SARS-CoV-2感染。本研究报告了疫苗接种对COVID-19的影响，并评估了不同疫苗剂量对常规实验室标志物的影响。
未经评估：入院时的实验室数据，2021年12月8日至2022年1月20日在西安住院的231例COVID-19病例，包括血常规,淋巴细胞亚型，凝固功能测试，收集并分析了病毒特异性抗体和血液生化测试。
未经批准：在231名患者中，21人没有接种疫苗，158例接种两剂，52例接种三剂。未接种疫苗的患者出现中度和重度症状的比例高于接种疫苗的患者,而接种2剂疫苗的患者比例高于接种3剂疫苗的患者.与未接种疫苗的患者相比，接种疫苗的患者中SARS-CoV-2特异性IgG水平显着升高。特别是,未接种疫苗的患者淋巴细胞计数和百分比较低，嗜酸性粒细胞和CD8+T淋巴细胞，和凝血相关标志物升高。此外,疫苗接种对肝肾功能无影响.
未经批准：接种SARS-CoV-2疫苗，诱导高IgG水平和增加CD8+T细胞和嗜酸性粒细胞，调节凝血功能，可以显着减轻COVID-19的症状，这表明该疫苗对SARS-CoV-2仍然具有保护作用。
未经评估：入院时的实验室数据，2021年12月8日至2022年1月20日在西安住院的231例COVID-19病例，包括血常规,淋巴细胞亚型，凝固功能测试，收集并分析了病毒特异性抗体和血液生化测试。
未经批准：在231名患者中，21人没有接种疫苗，158例接种两剂，52例接种三剂。未接种疫苗的患者出现中度和重度症状的比例高于接种疫苗的患者,而接种2剂疫苗的患者比例高于接种3剂疫苗的患者.与未接种疫苗的患者相比，接种疫苗的患者中SARS-CoV-2特异性IgG水平显着升高。特别是,未接种疫苗的患者淋巴细胞计数和百分比较低，嗜酸性粒细胞和CD8+T淋巴细胞，和凝血相关标志物升高。此外,疫苗接种对肝肾功能无影响.
未经批准：接种SARS-CoV-2疫苗，诱导高IgG水平和增加CD8+T细胞和嗜酸性粒细胞，调节凝血功能，可以显着减轻COVID-19的症状，这表明该疫苗对SARS-CoV-2仍然具有保护作用。
