PDF(Pubmed)
Abstract：
UNASSIGNED: To assess the relationship between high-resolution computed tomography (HRCT) abnormalities and clinical phenotypes of bronchopulmonary dysplasia (BPD).
UNASSIGNED: A retrospective, single-center study was carried out at the Children\'s Hospital of Fudan University between 2013 and 2020. Preterm infants born at ≤ 32 weeks\' gestation who were diagnosed with BPD and had HRCT between 40 and 50 weeks postmenstrual age (PMA)were included in the study. HRCT images from six pulmonary lobes were scored based on seven types of pulmonary lesions from two categories: hyperaeration lesions and parenchymal lesions. The hyperaeration score (HS) included scores of decreased attenuation, mosaic attenuation, and bulla/bleb, while the parenchymal score (PS) included those of linear lesion, consolidation, bronchial wall thickening, and bronchiectasis. All seven scores were summed up to create the total score (TS). One-way ANOVA testing or Kruskal-Wallis testing was adopted for the comparison of HRCT scores with BPD severity and clinical phenotypes. The correlation between HRCT scores and clinical phenotypes was evaluated by Spearman\'s correlation analysis.
UNASSIGNED: A total of 81 cases were included in the study. Cases with more severe BPD had a higher TS (p = 0.01), HS (p = 0.02), PS (p = 0.02), mosaic attenuation score (p = 0.03), bulla/Bleb score (p = 0.03), and linear density score (p = 0.01). TS (r = 0.28), PS (r = 0.35), linear density (r = 0.34), and consolidation (r = 0.24) were correlated with pulmonary hypertension (PH). However, no HRCT score was significantly different between the patients with or without tracheobronchomalacia (TBM). BPD patients with a combination of lung parenchymal disease, PH, and TBM had the highest TS and HS.
UNASSIGNED: HRCT scores correlated with BPD severity and PH in our study. HS might be a useful tool in the assessment of BPD severity while linear densities and consolidation might be helpful in predicting PH.
UNASSIGNED: A retrospective, single-center study was carried out at the Children\'s Hospital of Fudan University between 2013 and 2020. Preterm infants born at ≤ 32 weeks\' gestation who were diagnosed with BPD and had HRCT between 40 and 50 weeks postmenstrual age (PMA)were included in the study. HRCT images from six pulmonary lobes were scored based on seven types of pulmonary lesions from two categories: hyperaeration lesions and parenchymal lesions. The hyperaeration score (HS) included scores of decreased attenuation, mosaic attenuation, and bulla/bleb, while the parenchymal score (PS) included those of linear lesion, consolidation, bronchial wall thickening, and bronchiectasis. All seven scores were summed up to create the total score (TS). One-way ANOVA testing or Kruskal-Wallis testing was adopted for the comparison of HRCT scores with BPD severity and clinical phenotypes. The correlation between HRCT scores and clinical phenotypes was evaluated by Spearman\'s correlation analysis.
UNASSIGNED: A total of 81 cases were included in the study. Cases with more severe BPD had a higher TS (p = 0.01), HS (p = 0.02), PS (p = 0.02), mosaic attenuation score (p = 0.03), bulla/Bleb score (p = 0.03), and linear density score (p = 0.01). TS (r = 0.28), PS (r = 0.35), linear density (r = 0.34), and consolidation (r = 0.24) were correlated with pulmonary hypertension (PH). However, no HRCT score was significantly different between the patients with or without tracheobronchomalacia (TBM). BPD patients with a combination of lung parenchymal disease, PH, and TBM had the highest TS and HS.
UNASSIGNED: HRCT scores correlated with BPD severity and PH in our study. HS might be a useful tool in the assessment of BPD severity while linear densities and consolidation might be helpful in predicting PH.
摘要：
UNASSIGNED：评估高分辨率计算机断层扫描（HRCT）异常与支气管肺发育不良（BPD）临床表型之间的关系。
未经评估：回顾，单中心研究于2013年至2020年在复旦大学附属儿童医院进行。这项研究包括在妊娠≤32周时出生的早产儿，这些早产儿被诊断为BPD，并且在月经后40至50周龄（PMA）之间有HRCT。根据两类肺部病变的七种类型对来自六个肺叶的HRCT图像进行评分：过度通气病变和实质病变。高通气评分（HS）包括衰减降低的评分，马赛克衰减，和bulla/bleb，而实质评分（PS）包括线性病变，合并，支气管壁增厚，还有支气管扩张.将所有七个分数进行汇总以创建总分(TS)。采用单向ANOVA测试或Kruskal-Wallis测试比较HRCT评分与BPD严重程度和临床表型。采用Spearman相关分析评价HRCT评分与临床表型的相关性。
未经评估：共81例病例纳入研究。BPD更严重的病例有更高的TS（p=0.01），HS（p=0.02），PS（p=0.02），马赛克衰减分数（p=0.03），bulla/Bleb评分（p=0.03），和线性密度评分（p=0.01）。TS（r=0.28），PS（r=0.35），线密度(r=0.34)，合并（r=0.24）与肺动脉高压（PH）相关。然而,有或没有气管支气管软化症（TBM）的患者之间无HRCT评分显着差异。合并肺实质疾病的BPD患者，PH,TBM的TS和HS最高。
未经证实：在我们的研究中，HRCT评分与BPD严重程度和PH相关。HS可能是评估BPD严重程度的有用工具，而线密度和固结可能有助于预测PH。
未经评估：回顾，单中心研究于2013年至2020年在复旦大学附属儿童医院进行。这项研究包括在妊娠≤32周时出生的早产儿，这些早产儿被诊断为BPD，并且在月经后40至50周龄（PMA）之间有HRCT。根据两类肺部病变的七种类型对来自六个肺叶的HRCT图像进行评分：过度通气病变和实质病变。高通气评分（HS）包括衰减降低的评分，马赛克衰减，和bulla/bleb，而实质评分（PS）包括线性病变，合并，支气管壁增厚，还有支气管扩张.将所有七个分数进行汇总以创建总分(TS)。采用单向ANOVA测试或Kruskal-Wallis测试比较HRCT评分与BPD严重程度和临床表型。采用Spearman相关分析评价HRCT评分与临床表型的相关性。
未经评估：共81例病例纳入研究。BPD更严重的病例有更高的TS（p=0.01），HS（p=0.02），PS（p=0.02），马赛克衰减分数（p=0.03），bulla/Bleb评分（p=0.03），和线性密度评分（p=0.01）。TS（r=0.28），PS（r=0.35），线密度(r=0.34)，合并（r=0.24）与肺动脉高压（PH）相关。然而,有或没有气管支气管软化症（TBM）的患者之间无HRCT评分显着差异。合并肺实质疾病的BPD患者，PH,TBM的TS和HS最高。
未经证实：在我们的研究中，HRCT评分与BPD严重程度和PH相关。HS可能是评估BPD严重程度的有用工具，而线密度和固结可能有助于预测PH。
