PDF(Pubmed)
Abstract：
Breast cancer has recently been known as the first lethal malignancy in women worldwide. Despite the existing treatments that have improved the patients\' prognosis, some types of breast cancer are serious challenges to treat. Therefore, efforts are underway to provide more efficient therapy. Cryptotanshinone (CPT) is a liposoluble diterpenoid derivation of a traditional Chinese herbal medicine called Salvia miltiorrhiza Bunge. It has been considered in the past decades due to its vast therapeutic properties, including anti-tumor, anti-inflammatory, and anti-fibrosis. Recently, studies have found that CPT showed a significant anti-breast cancer effect in vivo and in vitro through different physiological and immunological mechanisms. This study summarized the latest research findings on the antitumor effect of CPT in breast cancer. Further, the main molecular mechanisms based on breast cancer types and combination with other drugs were reviewed to provide essential evidence for future longitudinal research and its clinical application in breast cancer treatment.
摘要：
乳腺癌最近被认为是世界上女性的第一个致命恶性肿瘤。尽管现有的治疗方法改善了患者的预后，某些类型的乳腺癌是严重的治疗挑战。因此,正在努力提供更有效的治疗。隐丹参酮（CPT）是一种称为丹参的传统中草药的脂溶性二萜衍生物。在过去的几十年中，由于其巨大的治疗特性，包括抗肿瘤，抗炎,和抗纤维化。最近,研究发现,CPT通过不同的生理和免疫机制,在体内和体外表现出显著的抗乳腺癌作用。本研究总结了CPT对乳腺癌抗肿瘤作用的最新研究成果。Further,综述了基于乳腺癌类型和与其他药物联合应用的主要分子机制，为今后的纵向研究及其在乳腺癌治疗中的临床应用提供必要的证据。
