PDF(Pubmed)
Abstract：
UNASSIGNED: Interindividual differences in response to personalized nutrition (PN) intervention were affected by multiple factors, including genetic backgrounds and gut microbiota. The fat mass and obesity associated (FTO) gene is an important factor related to hyperlipidemia and occurrence of cardiovascular diseases. However, few studies have explored the differences in response to intervention among subjects with different genotypes of FTO, and the associations between gut microbiota and individual responses.
UNASSIGNED: To explore the differential lipid metabolism outcomes associated with FTO gene polymorphisms in response to PN intervention, the altered taxonomic features of gut microbiota caused by the intervention, and the associations between gut microbiota and lipid metabolism outcomes.
UNASSIGNED: A total of 400 overweight or obese adults were recruited in the study and randomly divided into the PN group and control group, of whom 318 completed the 12-week intervention. The single nucleotide polymorphism (SNP) of rs1121980 in FTO was genotyped. Gut microbiota and blood lipids were determined at baseline and week 12. Functional property of microbiota was predicted using Tax4Fun functional prediction analysis.
UNASSIGNED: Subjects with the risk genotype of FTO had significantly higher weight and waist circumference (WC) at baseline. Generalized linear regression models showed that the reduction in weight, body mass index (BMI), WC, body fat percentage, total cholesterol (TCHO), and low-density lipoprotein (LDL) was greater in subjects with the risk genotype of FTO and in the PN group. Significant interaction effects between genotype and intervention on weight, BMI, WC, TCHO, and LDL were found after stratifying for specific genotype of FTO. All subjects showed significant increasement in α diversity of gut microbiota after intervention except for those with the non-risk genotype in the control group. Gut microbiota, including Blautia and Firmicutes, might be involved in lipid metabolism in response to interventions. The predicted functions of the microbiota in subjects with different genotypes were related to lipid metabolism-related pathways, including fatty acid biosynthesis and degradation.
UNASSIGNED: Subjects with the risk genotype of FTO had better response to nutrition intervention, and PN intervention showed better amelioration in anthropometric parameters and blood lipids than the control. Gut microbiota might be involved in modulating differential lipid metabolism responses to intervention in subjects with different genotypes.
UNASSIGNED: [Chictr.org.cn], identifier [ChiCTR1900026226].
UNASSIGNED: To explore the differential lipid metabolism outcomes associated with FTO gene polymorphisms in response to PN intervention, the altered taxonomic features of gut microbiota caused by the intervention, and the associations between gut microbiota and lipid metabolism outcomes.
UNASSIGNED: A total of 400 overweight or obese adults were recruited in the study and randomly divided into the PN group and control group, of whom 318 completed the 12-week intervention. The single nucleotide polymorphism (SNP) of rs1121980 in FTO was genotyped. Gut microbiota and blood lipids were determined at baseline and week 12. Functional property of microbiota was predicted using Tax4Fun functional prediction analysis.
UNASSIGNED: Subjects with the risk genotype of FTO had significantly higher weight and waist circumference (WC) at baseline. Generalized linear regression models showed that the reduction in weight, body mass index (BMI), WC, body fat percentage, total cholesterol (TCHO), and low-density lipoprotein (LDL) was greater in subjects with the risk genotype of FTO and in the PN group. Significant interaction effects between genotype and intervention on weight, BMI, WC, TCHO, and LDL were found after stratifying for specific genotype of FTO. All subjects showed significant increasement in α diversity of gut microbiota after intervention except for those with the non-risk genotype in the control group. Gut microbiota, including Blautia and Firmicutes, might be involved in lipid metabolism in response to interventions. The predicted functions of the microbiota in subjects with different genotypes were related to lipid metabolism-related pathways, including fatty acid biosynthesis and degradation.
UNASSIGNED: Subjects with the risk genotype of FTO had better response to nutrition intervention, and PN intervention showed better amelioration in anthropometric parameters and blood lipids than the control. Gut microbiota might be involved in modulating differential lipid metabolism responses to intervention in subjects with different genotypes.
UNASSIGNED: [Chictr.org.cn], identifier [ChiCTR1900026226].
摘要：
UNASSIGNED：对个性化营养（PN）干预的个体差异受多种因素影响，包括遗传背景和肠道微生物群。脂肪量与肥胖相关(FTO)基因是与高脂血症和心血管疾病发生有关的重要因素。然而,很少有研究探讨不同FTO基因型受试者对干预反应的差异，以及肠道微生物群和个体反应之间的关联。
UNASSIGNED：为了探索与FTO基因多态性相关的不同的脂质代谢结局，干预引起的肠道微生物群分类学特征的改变，以及肠道菌群与脂质代谢结果之间的关联。
UNASSIGNED：本研究共招募了400名超重或肥胖的成年人，随机分为PN组和对照组，其中318人完成了为期12周的干预。对FTO中rs1121980的单核苷酸多态性（SNP）进行了基因分型。在基线和第12周测定肠道微生物群和血脂。使用Tax4Fun功能预测分析预测微生物群的功能特性。
UNASSIGNED：具有FTO风险基因型的受试者在基线时的体重和腰围（WC）明显更高。广义线性回归模型表明，体重的减少，体重指数（BMI），WC,身体脂肪百分比，总胆固醇（TCHO），具有FTO风险基因型的受试者和PN组的低密度脂蛋白（LDL）更高。基因型和干预对体重的显著交互作用，BMI,WC,TCHO,对FTO的特定基因型进行分层后发现LDL。干预后，除对照组中具有非风险基因型的受试者外，所有受试者的肠道菌群α多样性均显着增加。肠道菌群,包括Blautia和Firmicutes,可能参与脂质代谢对干预的反应。不同基因型受试者的微生物群的预测功能与脂质代谢相关通路有关，包括脂肪酸的生物合成和降解。
UNASSIGNED：具有FTO风险基因型的受试者对营养干预有更好的反应，与对照组相比，PN干预在人体测量参数和血脂方面表现出更好的改善。肠道菌群可能参与调节不同基因型受试者对干预的不同脂质代谢反应。
UNASSIGNED:[Chictr.org.cn],标识符[ChiCTR1900026226]。
UNASSIGNED：为了探索与FTO基因多态性相关的不同的脂质代谢结局，干预引起的肠道微生物群分类学特征的改变，以及肠道菌群与脂质代谢结果之间的关联。
UNASSIGNED：本研究共招募了400名超重或肥胖的成年人，随机分为PN组和对照组，其中318人完成了为期12周的干预。对FTO中rs1121980的单核苷酸多态性（SNP）进行了基因分型。在基线和第12周测定肠道微生物群和血脂。使用Tax4Fun功能预测分析预测微生物群的功能特性。
UNASSIGNED：具有FTO风险基因型的受试者在基线时的体重和腰围（WC）明显更高。广义线性回归模型表明，体重的减少，体重指数（BMI），WC,身体脂肪百分比，总胆固醇（TCHO），具有FTO风险基因型的受试者和PN组的低密度脂蛋白（LDL）更高。基因型和干预对体重的显著交互作用，BMI,WC,TCHO,对FTO的特定基因型进行分层后发现LDL。干预后，除对照组中具有非风险基因型的受试者外，所有受试者的肠道菌群α多样性均显着增加。肠道菌群,包括Blautia和Firmicutes,可能参与脂质代谢对干预的反应。不同基因型受试者的微生物群的预测功能与脂质代谢相关通路有关，包括脂肪酸的生物合成和降解。
UNASSIGNED：具有FTO风险基因型的受试者对营养干预有更好的反应，与对照组相比，PN干预在人体测量参数和血脂方面表现出更好的改善。肠道菌群可能参与调节不同基因型受试者对干预的不同脂质代谢反应。
UNASSIGNED:[Chictr.org.cn],标识符[ChiCTR1900026226]。
