PDF(Pubmed)
Abstract：
Cholesterol gallstones are very common in hepatobiliary surgery and have been studied to a certain extent by doctors worldwide for decades. However, the mechanism of cholesterol gallstone formation is not fully understood, so there is currently no completely effective drug for the treatment and prevention of cholesterol gallstones. The formation and development of cholesterol gallstones are caused by a variety of genetic and environmental factors, among which genetic susceptibility, intestinal microflora disorders, impaired gallbladder motility, and immune disorders are important in the pathogenesis of cholesterol gallstones. This review focuses on recent advances in these mechanisms. We also discuss some new targets that may be effective in the treatment and prevention of cholesterol gallstones, which may be hot areas in the future.
摘要：
胆固醇胆结石在肝胆外科手术中非常常见，几十年来，全世界的医生都在一定程度上进行了研究。然而,胆固醇结石形成的机制还不完全清楚，因此，目前尚无完全有效的治疗和预防胆固醇胆结石的药物。胆固醇胆结石的形成和发展是由多种遗传和环境因素引起的，其中遗传易感性，肠道菌群紊乱,胆囊运动受损，免疫紊乱在胆固醇胆结石的发病机制中起着重要作用。本综述侧重于这些机制的最新进展。我们还讨论了一些可能有效治疗和预防胆固醇胆结石的新靶点，这可能是未来的热点地区。
