PDF(Pubmed)
Abstract：
The proportion of non-cancer death in patients with esophagus cancer (EC) still increasing, especially cardiovascular disease (CVD) related death. The aim of this study was assess non-cancer causes of death and identified independent risk factors of CVD related death in EC patients. Patients diagnosed with EC were extracted from the Surveillance, Epidemiology, and End Result database (SEER) database for analysis. Standardized mortality rates (SMRs) for non-EC deaths were calculated, the risk of death were assessed and compared with US general population. Multivariate competitive risk analysis were performed to select independent risk factors for death from CVD in EC patients. A total of 43739 EC patients were enrolled and 35139 died during follow-up, of which 4248 died from non-cancer cause of death. The risk of non-cancer death in EC patients was 2.27-fold higher than in the general population (SMR=2.27; 95% CI, 2.20-2.34). CVD were the most important cause of non-cancer death in EC patients, accounting for 43.4% of non-cancer of deaths. Compare with the general population, EC patients have higher risk of death from disease of heart (SMR, 2.24; 95% CI, 2.13-2.35), pneumonia and influenza (SMR, 2.92; 95% CI, 2.50-3.39), septicemia (SMR, 5.01; 95% CI, 4.30-5.79), along with other causes. Patients with advanced age and patients who received radiotherapy has higher risk of death caused by CVD, patients with female sex, poor differentiated and undifferentiated, regional and distant stage, married, diagnosed between 2010-2016 has lower risk of CVD related death, compared with patients without any treatment measures, patients received chemotherapy alone has lower risk of death from CVD. Non-cancer cause of death has become an important cause of death in EC patients. Improving public awareness of the major risk factors for non-cancer death is beneficial to the prevention and treatment of malignant tumors.
摘要：
食管癌（EC）患者的非癌症死亡比例仍在增加，尤其是心血管疾病（CVD）相关的死亡。这项研究的目的是评估非癌症死亡原因，并确定EC患者CVD相关死亡的独立危险因素。从监测中提取诊断为EC的患者，流行病学,和最终结果数据库(SEER)数据库进行分析。计算非EC死亡的标准化死亡率（SMR），对死亡风险进行了评估,并与美国普通人群进行了比较.采用多因素竞争风险分析选择EC患者CVD死亡的独立危险因素。共纳入43739例EC患者，35139例患者在随访期间死亡。其中4248人死于非癌症死因。EC患者的非癌症死亡风险比一般人群高2.27倍（SMR=2.27；95％CI，2.20-2.34）。CVD是EC患者非癌症死亡的最重要原因，占非癌症死亡人数的43.4%。与普通人群相比，EC患者有更高的心脏病死亡风险(SMR，2.24；95%CI，2.13-2.35)，肺炎和流感（SMR，2.92；95%CI，2.50-3.39），败血症（SMR，5.01；95%CI，4.30-5.79)，以及其他原因。高龄患者和接受放疗的患者因CVD引起的死亡风险较高，女性患者，差的分化和未分化，区域和遥远的阶段，已婚,在2010-2016年之间诊断出CVD相关死亡的风险较低，与没有任何治疗措施的患者相比，仅接受化疗的患者心血管疾病死亡风险较低.非癌症死亡原因已成为EC患者的重要死亡原因。提高公众对非癌症死亡主要危险因素的认识,有利于恶性肿瘤的预防和治疗。
