Abstract：
Oxygen therapy is vital in adult intensive care unit (ICU) patients, but it is indistinct whether higher or lower oxygen targets are favorable. Our aim was to update the findings of randomized controlled trials (RTCs) comparing higher and lower oxygen strategies.
MEDLINE, EMBASE, and Web of Science were searched. RCTs comparing higher (liberal, hyperoxia) and lower (conservative, normoxia) oxygen in adult mechanically ventilated ICU patients were included. The main outcome was 90-day mortality; other outcomes include serious adverse events (SAE), support free days and length of stay (LOS).
No significant difference was observed for 90-day mortality. A lower incidence was found for SAEs, favoring lower oxygenation (OR, 0.86; 95%CI, 0.77-0.96; I 2 13%). No differences were observed in either support free days at day 28 or ICU and hospital LOS.
No difference was found for 90-day mortality, support free days and ICU and hospital LOS. However, a lower incidence of SAEs was found for lower oxygenation. These findings may have clinical implications for practice guidelines, yet it remains of paramount importance to continue conducting clinical trials, comparing groups with a clinically relevant contrast and focusing on the impact of important side effects.
MEDLINE, EMBASE, and Web of Science were searched. RCTs comparing higher (liberal, hyperoxia) and lower (conservative, normoxia) oxygen in adult mechanically ventilated ICU patients were included. The main outcome was 90-day mortality; other outcomes include serious adverse events (SAE), support free days and length of stay (LOS).
No significant difference was observed for 90-day mortality. A lower incidence was found for SAEs, favoring lower oxygenation (OR, 0.86; 95%CI, 0.77-0.96; I 2 13%). No differences were observed in either support free days at day 28 or ICU and hospital LOS.
No difference was found for 90-day mortality, support free days and ICU and hospital LOS. However, a lower incidence of SAEs was found for lower oxygenation. These findings may have clinical implications for practice guidelines, yet it remains of paramount importance to continue conducting clinical trials, comparing groups with a clinically relevant contrast and focusing on the impact of important side effects.
摘要：
氧疗在成人重症监护病房（ICU）患者中至关重要，但是尚不清楚更高或更低的氧气目标是否有利。我们的目的是更新比较高和低氧气策略的随机对照试验（RTC）的结果。
MEDLINE,EMBASE,搜索了WebofScience。RCT比较较高(自由主义，高氧)和较低(保守，normoxia）包括成人机械通气ICU患者的氧气。主要结果是90天死亡率；其他结果包括严重不良事件（SAE），支持免费天数和停留时间(LOS)。
90天死亡率没有观察到显著差异。发现SAE的发生率较低，有利于低氧合(或，0.86；95CI，0.77-0.96；I213%）。在第28天的无支持日或ICU和医院LOS中均未观察到差异。
90天死亡率没有差异，支持免费天数和ICU和医院LOS。然而,SAE的发生率较低,氧合降低.这些发现可能对实践指南有临床意义，然而，继续进行临床试验仍然至关重要，比较组与临床相关的对比，并关注重要副作用的影响。
MEDLINE,EMBASE,搜索了WebofScience。RCT比较较高(自由主义，高氧)和较低(保守，normoxia）包括成人机械通气ICU患者的氧气。主要结果是90天死亡率；其他结果包括严重不良事件（SAE），支持免费天数和停留时间(LOS)。
90天死亡率没有观察到显著差异。发现SAE的发生率较低，有利于低氧合(或，0.86；95CI，0.77-0.96；I213%）。在第28天的无支持日或ICU和医院LOS中均未观察到差异。
90天死亡率没有差异，支持免费天数和ICU和医院LOS。然而,SAE的发生率较低,氧合降低.这些发现可能对实践指南有临床意义，然而，继续进行临床试验仍然至关重要，比较组与临床相关的对比，并关注重要副作用的影响。
