PDF(Pubmed)
Abstract：
Cryptorchidism (CO) or undescended testicle is an abnormality of male gonadal development that can generate long-term repercussions in men, such as infertility and germ cell neoplasia in situ (GCNIS). The origin of these alterations in humans is not completely clear, due to the absence of an animal model with similar testicular development as in humans with CO. This work intends to describe the testicular histological development of dogs with congenital CO, and determine whether the species could adequately serve as a study model for this pathology in humans. The study was carried out with 36 dogs, equally distributed in two groups: healthy control (CTRL) and CO groups. The contralateral testis to the undescended one in CO group of the animals was considered and analyzed. Each group was subdivided in three stages of development: (1) peripubertal stage (6-8 months), (2) young adult (9-48 months) and (3) senile (49-130 months). Histological development, the presence of cells with gonocyte morphology, cell proliferation, testicular lipoperoxidation and hormonal concentrations of testosterone, estradiol, FSH and LH were evaluated and described. In the cryptorchid testes, the first histological alterations appeared from the first stage of development and were maintained until the senile stage. A pronounced testicular lipoperoxidation occurred only in the second stage of development. The histological alterations due to CO were markedly evident in the young adult stage. Testosterone concentrations witnessed a decrease starting from in the second stage and kept on until the last stage. The contralateral testes of the CO animals showed alterations that positioned them between the control and CO testes. Testicular development of dogs with CO is similar to that of humans. The results of the study suggest that this species could serve as a suitable model for the study of CO in humans.
摘要：
隐睾（CO）或未降睾丸是男性性腺发育的异常，可以在男性中产生长期影响，如不育和生殖细胞瘤原位（GCNIS）。这些改变在人类中的起源尚不完全清楚，由于缺乏与CO患者睾丸发育相似的动物模型。这项工作旨在描述患有先天性CO的狗的睾丸组织学发育，并确定该物种是否可以充分用作人类这种病理学的研究模型。这项研究是对36只狗进行的，平均分布在两组：健康对照组（CTRL）和CO组。考虑并分析了CO组动物中未降睾丸的对侧睾丸。每组分为三个发育阶段：（1）青春期（6-8个月），（2）青年（9-48个月）和（3）老年（49-130个月）。组织学发展,存在具有性腺细胞形态的细胞，细胞增殖，睾丸脂质过氧化和睾酮的激素浓度，雌二醇,对FSH和LH进行评价和描述。在密匙睾丸中，最初的组织学改变从发育的第一阶段开始出现，并一直维持到老年阶段。明显的睾丸脂质过氧化仅在发育的第二阶段发生。在年轻的成年阶段，由于CO引起的组织学改变非常明显。睾酮浓度从第二阶段开始下降，一直持续到最后阶段。CO动物的对侧睾丸显示出改变，将其置于对照和CO睾丸之间。患有CO的狗的睾丸发育与人类相似。研究结果表明，该物种可以作为研究人类CO的合适模型。
