Abstract：
OBJECTIVE: The improvements in survival with expansion of the survivors\' population, along with evolution of endoscopically-based treatment modalities, have contributed to emphasize the clinical relevance of recurrences in sinonasal cancers. However, at present, literature is scant regarding the pattern of recurrences and the therapeutic strategies available to manage long survivors who experienced single or multiple failures. The aim of the present study was to analyze sinonasal cancers recurrences to provide data regarding rates and patterns of relapse, predictors of failure and prognostic impact of the recurrence.
METHODS: All patients receiving multimodal treatments including endoscopic surgery between 1995 and 2021 in three European referral centers were included. Statistical analysis of survival was performed through univariable, multivariable and unidirectional multistate models. Survival after recurrence analysis was implemented for patients experiencing at least one recurrence.
RESULTS: The 5- and 10-year recurrence free survival rates were 34.1% and 38.4% for the whole population. With a mean follow-up time of 60 months, a global recurrence rate of 32.9% was observed. The 5- and 10-year survival after recurrence rates were 27.2% and 21.7%, respectively. Incidence and rates of recurrences were significantly associated with histology subtypes.
CONCLUSIONS: This study provides valuable oncologic outcomes regarding a large homogenous cohort of patients affected by sinonasal malignances treated within a multimodal framework, emphasizing the strong correlation of histologic type with prognosis, as well as with pattern of recurrences.
METHODS: All patients receiving multimodal treatments including endoscopic surgery between 1995 and 2021 in three European referral centers were included. Statistical analysis of survival was performed through univariable, multivariable and unidirectional multistate models. Survival after recurrence analysis was implemented for patients experiencing at least one recurrence.
RESULTS: The 5- and 10-year recurrence free survival rates were 34.1% and 38.4% for the whole population. With a mean follow-up time of 60 months, a global recurrence rate of 32.9% was observed. The 5- and 10-year survival after recurrence rates were 27.2% and 21.7%, respectively. Incidence and rates of recurrences were significantly associated with histology subtypes.
CONCLUSIONS: This study provides valuable oncologic outcomes regarding a large homogenous cohort of patients affected by sinonasal malignances treated within a multimodal framework, emphasizing the strong correlation of histologic type with prognosis, as well as with pattern of recurrences.
摘要：
目的：随着幸存者人口的扩大，生存率的提高，随着基于内窥镜的治疗方式的发展，有助于强调鼻窦肿瘤复发的临床相关性。然而,目前,关于复发模式和可用于管理经历单发或多发失败的长期幸存者的治疗策略的文献很少.本研究的目的是分析鼻窦肿瘤的复发，以提供有关复发率和模式的数据。失败的预测因子和复发的预后影响。
方法：纳入了1995年至2021年在三个欧洲转诊中心接受包括内镜手术在内的多模式治疗的所有患者。通过单变量对生存率进行统计分析，多变量和单向多状态模型。对经历至少一次复发的患者实施复发后的存活分析。
结果：全人群5年和10年无复发生存率分别为34.1%和38.4%。平均随访时间为60个月，全球复发率为32.9%.术后5年和10年生存率分别为27.2%和21.7%,分别。发病率和复发率与组织学亚型显着相关。
结论：本研究提供了在多模式框架内治疗的大量同质鼻窦恶性肿瘤患者的有价值的肿瘤学结果，强调组织学类型与预后的强相关性，以及复发模式。
方法：纳入了1995年至2021年在三个欧洲转诊中心接受包括内镜手术在内的多模式治疗的所有患者。通过单变量对生存率进行统计分析，多变量和单向多状态模型。对经历至少一次复发的患者实施复发后的存活分析。
结果：全人群5年和10年无复发生存率分别为34.1%和38.4%。平均随访时间为60个月，全球复发率为32.9%.术后5年和10年生存率分别为27.2%和21.7%,分别。发病率和复发率与组织学亚型显着相关。
结论：本研究提供了在多模式框架内治疗的大量同质鼻窦恶性肿瘤患者的有价值的肿瘤学结果，强调组织学类型与预后的强相关性，以及复发模式。
