Abstract：
OBJECTIVE: To investigate the effects of periopathogens on bone grafts for maxillary sinus floor augmentation and implant survival.
METHODS: A cohort study was designed. Samples from maxillary sinus floor augmentation sites and from periodontal pockets in adjacent teeth of the same patients were collected during the surgery and following periodontal maintenance and plaque removal. Polymerase chain reaction (PCR) was performed by an external lab service for analysis of the following periopathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola. Correlations between the presence of periopathogens in sinus sites and periodontal pockets in adjacent teeth and the clinical findings (bone and implant survival) were studied.
RESULTS: A total of 23 patients were suitable for study inclusion. Periopathogens were found in sinus sites in 6 patients (26%) and in tooth sites in 15 patients (65%). There was low correlation for the presence of periopathogens between tooth sites and sinus sites and for complications.
CONCLUSIONS: The presence of periopathogens as revealed by PCR was lower in sinus sites compared with tooth sites. Their presence neither caused bone pathology nor affected dental implant survival. The presence of periopathogens in sinus sites is inevitable even under periodontal maintenance. Although its presence did not endanger implant survival, future studies are recommended for studying this issue. Further analyses of the presence of periopathogens in cases of bone resorption at the apex of dental implants inserted into sites of augmented sinuses are warranted.
METHODS: A cohort study was designed. Samples from maxillary sinus floor augmentation sites and from periodontal pockets in adjacent teeth of the same patients were collected during the surgery and following periodontal maintenance and plaque removal. Polymerase chain reaction (PCR) was performed by an external lab service for analysis of the following periopathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola. Correlations between the presence of periopathogens in sinus sites and periodontal pockets in adjacent teeth and the clinical findings (bone and implant survival) were studied.
RESULTS: A total of 23 patients were suitable for study inclusion. Periopathogens were found in sinus sites in 6 patients (26%) and in tooth sites in 15 patients (65%). There was low correlation for the presence of periopathogens between tooth sites and sinus sites and for complications.
CONCLUSIONS: The presence of periopathogens as revealed by PCR was lower in sinus sites compared with tooth sites. Their presence neither caused bone pathology nor affected dental implant survival. The presence of periopathogens in sinus sites is inevitable even under periodontal maintenance. Although its presence did not endanger implant survival, future studies are recommended for studying this issue. Further analyses of the presence of periopathogens in cases of bone resorption at the apex of dental implants inserted into sites of augmented sinuses are warranted.
摘要：
目的：探讨上颌窦底强化和种植体成活对骨移植物的影响。
方法：设计了一项队列研究。在手术期间以及牙周维护和牙斑清除后，收集了同一患者上颌窦底部增加部位和相邻牙齿牙周袋的样品。聚合酶链反应（PCR）由外部实验室服务进行，用于分析以下围病原体：聚集杆菌放线菌，牙龈卟啉单胞菌,中间介体普雷沃特拉，连翘坦菌,和Denticola密螺旋体.研究了鼻窦部位周围病原菌的存在与相邻牙齿牙周袋的存在与临床发现（骨骼和植入物存活）之间的相关性。
结果：共有23例患者适合纳入研究。在6例患者（26％）的鼻窦部位和15例患者（65％）的牙齿部位发现了围手术期病原体。牙齿部位和鼻窦部位之间存在周病原以及并发症的相关性较低。
结论：通过PCR显示，与牙齿部位相比，鼻窦部位周围病原体的存在较低。它们的存在既不会引起骨病理学，也不会影响牙种植体的存活。即使在牙周维持下，鼻窦部位也不可避免地存在周围病原体。虽然它的存在并没有危及植入物的存活，建议未来的研究来研究这个问题。有必要进一步分析在插入增大的鼻窦部位的牙植入物的根尖处发生骨吸收的情况下，周发病原体的存在。
方法：设计了一项队列研究。在手术期间以及牙周维护和牙斑清除后，收集了同一患者上颌窦底部增加部位和相邻牙齿牙周袋的样品。聚合酶链反应（PCR）由外部实验室服务进行，用于分析以下围病原体：聚集杆菌放线菌，牙龈卟啉单胞菌,中间介体普雷沃特拉，连翘坦菌,和Denticola密螺旋体.研究了鼻窦部位周围病原菌的存在与相邻牙齿牙周袋的存在与临床发现（骨骼和植入物存活）之间的相关性。
结果：共有23例患者适合纳入研究。在6例患者（26％）的鼻窦部位和15例患者（65％）的牙齿部位发现了围手术期病原体。牙齿部位和鼻窦部位之间存在周病原以及并发症的相关性较低。
结论：通过PCR显示，与牙齿部位相比，鼻窦部位周围病原体的存在较低。它们的存在既不会引起骨病理学，也不会影响牙种植体的存活。即使在牙周维持下，鼻窦部位也不可避免地存在周围病原体。虽然它的存在并没有危及植入物的存活，建议未来的研究来研究这个问题。有必要进一步分析在插入增大的鼻窦部位的牙植入物的根尖处发生骨吸收的情况下，周发病原体的存在。
