关键词: doublet toxicity morcellation trabectedin uterine leiomyosarcoma uterine myomas

来  源:   DOI:10.2217/fon-2022-0637

Abstract:
Uterine fibroids are difficult to distinguish from malignant masses using standard ultrasonography; and morcellation carries the risk of disseminating occult cancer in a small but relevant group of women with an undetected uterine malignancy. In this context, we follow the progress of a woman diagnosed with uterine leiomyosarcoma after suboptimal initial surgery for an assumed fibroid. Evidence is reviewed that guided multidisciplinary tumor board decisions about optimal management approaches after local seeding and development of distant metastases, and informed treatment selection at each line of therapy. As the case study illustrates, choice of treatment for advanced soft tissue sarcomas frequently involves finding an appropriate balance between the efficacy and toxicity of available options, aiming to allow patients to maintain their normal lives.
摘要:
使用标准超声检查很难将子宫肌瘤与恶性肿块区分开来;在一小部分但相关的未发现子宫恶性肿瘤的女性中,碎裂有传播隐匿性癌症的风险。在这种情况下,我们追踪了1名被诊断为子宫平滑肌肉瘤的女性患者的进展情况,该患者接受了假定的纤维瘤的初始手术效果欠佳.审查了指导多学科肿瘤委员会在局部播种和远处转移发展后关于最佳管理方法的决定的证据。和知情的治疗选择在每一行的治疗。正如案例研究所示,晚期软组织肉瘤的治疗选择通常涉及在可用选择的疗效和毒性之间找到适当的平衡,旨在让患者维持正常生活。
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