PDF(Pubmed)
Abstract：
UNASSIGNED: Nail changes in people living with human immunodeficiency virus (HIV) have been scarcely reported. The aim of this study was to establish the frequency and characteristics of nail alterations observed in adults with HIV infection in a third-level hospital in Mexico.
UNASSIGNED: Observational and cross-sectional study carried out in 205 patients receiving care at the HIV/AIDS Clinic of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) in Mexico City. We performed a nail and iconographic assessment of both hands and toenails. We collected information of demographic and clinical variables, as well as drugs use, and antiretroviral treatment used by the participants through a questionnaire and from medical records. We performed direct cytological examinations and nail mycological cultures in participants with symptoms of onychomycosis.
UNASSIGNED: The participants were predominantly male patients (91.2%), with a mean age of 41 (range 21-78) years, under antiretroviral therapy (91.2%), with a suppressed viral load (78.5%) and mean CD4+ lymphocyte count of 379.5 (range 20-1,162) cells/μL. Fitzpatrick\'s IV phototype was prevailing in the studied population (70%). Nail changes were documented in 72.2% of the patients; being pigmentary changes (37.1%) and trauma (30.7%) the most frequent. Onychomycosis was observed in 26.3%; with total dystrophic onychomycosis as the most frequent clinical variant (68.5%). We obtained fungal isolates in 59.3% of participants and Candida parapsilosis was the most frequent of these (37.5%).
UNASSIGNED: We observed a high prevalence of nail changes with very diverse etiology, as well as a variety of nondermatophytic yeasts and molds isolates associated with cases with onychomycosis. These findings reinforce and confirm the need for routine nail examination and stress the importance of medical personnel working with people living with HIV to have broad knowledge of nail pathology.
UNASSIGNED: Observational and cross-sectional study carried out in 205 patients receiving care at the HIV/AIDS Clinic of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) in Mexico City. We performed a nail and iconographic assessment of both hands and toenails. We collected information of demographic and clinical variables, as well as drugs use, and antiretroviral treatment used by the participants through a questionnaire and from medical records. We performed direct cytological examinations and nail mycological cultures in participants with symptoms of onychomycosis.
UNASSIGNED: The participants were predominantly male patients (91.2%), with a mean age of 41 (range 21-78) years, under antiretroviral therapy (91.2%), with a suppressed viral load (78.5%) and mean CD4+ lymphocyte count of 379.5 (range 20-1,162) cells/μL. Fitzpatrick\'s IV phototype was prevailing in the studied population (70%). Nail changes were documented in 72.2% of the patients; being pigmentary changes (37.1%) and trauma (30.7%) the most frequent. Onychomycosis was observed in 26.3%; with total dystrophic onychomycosis as the most frequent clinical variant (68.5%). We obtained fungal isolates in 59.3% of participants and Candida parapsilosis was the most frequent of these (37.5%).
UNASSIGNED: We observed a high prevalence of nail changes with very diverse etiology, as well as a variety of nondermatophytic yeasts and molds isolates associated with cases with onychomycosis. These findings reinforce and confirm the need for routine nail examination and stress the importance of medical personnel working with people living with HIV to have broad knowledge of nail pathology.
摘要：
未经评估：人类免疫缺陷病毒（HIV）感染者的指甲变化几乎没有报道。这项研究的目的是确定在墨西哥三级医院中感染HIV的成年人中观察到的指甲改变的频率和特征。
UNASSIGNED：对在墨西哥城萨尔瓦多国家研究所（INCMNSZ）的艾滋病毒/艾滋病诊所接受治疗的205名患者进行了观察性和横断面研究。我们对双手和脚趾甲进行了指甲和图像评估。我们收集了人口统计学和临床变量的信息，以及药物的使用，以及参与者通过问卷和医疗记录使用的抗逆转录病毒治疗。我们对有甲癣症状的参与者进行了直接细胞学检查和指甲真菌学培养。
未经评估：参与者主要是男性患者（91.2%），平均年龄为41岁（21-78岁），接受抗逆转录病毒治疗（91.2%），抑制病毒载量（78.5％）和平均CD4淋巴细胞计数为379.5（范围20-1,162）细胞/μL。Fitzpatrick的IV型在研究人群中普遍存在（70％）。在72.2％的患者中记录了指甲变化；色素变化（37.1％）和创伤（30.7％）最常见。在26.3％的病例中观察到甲真菌病；总的营养不良性甲真菌病是最常见的临床变异（68.5％）。我们在59.3％的参与者中获得了真菌分离株，其中近带念珠菌最常见（37.5％）。
未经评估：我们观察到指甲改变的患病率很高，病因非常不同，以及与甲癣病例相关的各种非皮肤癣菌和霉菌分离株。这些发现加强并证实了常规指甲检查的必要性，并强调了与HIV感染者一起工作的医务人员对指甲病理学具有广泛知识的重要性。
UNASSIGNED：对在墨西哥城萨尔瓦多国家研究所（INCMNSZ）的艾滋病毒/艾滋病诊所接受治疗的205名患者进行了观察性和横断面研究。我们对双手和脚趾甲进行了指甲和图像评估。我们收集了人口统计学和临床变量的信息，以及药物的使用，以及参与者通过问卷和医疗记录使用的抗逆转录病毒治疗。我们对有甲癣症状的参与者进行了直接细胞学检查和指甲真菌学培养。
未经评估：参与者主要是男性患者（91.2%），平均年龄为41岁（21-78岁），接受抗逆转录病毒治疗（91.2%），抑制病毒载量（78.5％）和平均CD4淋巴细胞计数为379.5（范围20-1,162）细胞/μL。Fitzpatrick的IV型在研究人群中普遍存在（70％）。在72.2％的患者中记录了指甲变化；色素变化（37.1％）和创伤（30.7％）最常见。在26.3％的病例中观察到甲真菌病；总的营养不良性甲真菌病是最常见的临床变异（68.5％）。我们在59.3％的参与者中获得了真菌分离株，其中近带念珠菌最常见（37.5％）。
未经评估：我们观察到指甲改变的患病率很高，病因非常不同，以及与甲癣病例相关的各种非皮肤癣菌和霉菌分离株。这些发现加强并证实了常规指甲检查的必要性，并强调了与HIV感染者一起工作的医务人员对指甲病理学具有广泛知识的重要性。
