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Abstract：
UNASSIGNED: To investigate the risk factors for lateral lymph node metastasis (LLNM) in papillary thyroid carcinoma (PTC).
UNASSIGNED: A retrospective analysis of 209 patients with PTC who underwent primary surgery at the Beijing Friendship Hospital affiliated with Capital Medical University from November 2014 to November 2018 was performed. The patients were divided into the LLNM group and the non-LLNM group. The clinical and pathological characteristics of the patients were analysed. The risk factors for LLNM were analysed by univariate and multivariate analyses.
UNASSIGNED: The incidence of LLNM was 13.4% in PTC patients. Univariate analysis showed that the maximum diameter of the primary tumour > 2 cm (P < 0.001), bilateral primary tumour (P = 0.020), extrathyroidal extension (ETE) (P < 0.001), central lymph node metastasis (CLNM) (P < 0.001), and CLNM number ≥ 5 (P < 0.001) were significantly associated with LLNM. Multivariate logistic regression analysis showed that the maximum diameter of the primary tumour > 2 cm, ETE, and CLNM were independent risk factors for LLNM (OR values were 3.880, 5.202, and 4.474, respectively). There were 6 patients with skip lateral cervical lymph node metastasis, accounting for 21% of all LLNM patients.
UNASSIGNED: This study revealed several independent risk factors for predicting LLNM in PTC patients, such as the maximum diameter of the primary tumour > 2 cm, ETE and CLNM. Lateral neck dissection may be recommended in PTC patients with those risk factors. Paying attention to the occurrence of skip lateral cervical lymph node metastasis during the clinical diagnosis and treatment processes is necessary.
UNASSIGNED: A retrospective analysis of 209 patients with PTC who underwent primary surgery at the Beijing Friendship Hospital affiliated with Capital Medical University from November 2014 to November 2018 was performed. The patients were divided into the LLNM group and the non-LLNM group. The clinical and pathological characteristics of the patients were analysed. The risk factors for LLNM were analysed by univariate and multivariate analyses.
UNASSIGNED: The incidence of LLNM was 13.4% in PTC patients. Univariate analysis showed that the maximum diameter of the primary tumour > 2 cm (P < 0.001), bilateral primary tumour (P = 0.020), extrathyroidal extension (ETE) (P < 0.001), central lymph node metastasis (CLNM) (P < 0.001), and CLNM number ≥ 5 (P < 0.001) were significantly associated with LLNM. Multivariate logistic regression analysis showed that the maximum diameter of the primary tumour > 2 cm, ETE, and CLNM were independent risk factors for LLNM (OR values were 3.880, 5.202, and 4.474, respectively). There were 6 patients with skip lateral cervical lymph node metastasis, accounting for 21% of all LLNM patients.
UNASSIGNED: This study revealed several independent risk factors for predicting LLNM in PTC patients, such as the maximum diameter of the primary tumour > 2 cm, ETE and CLNM. Lateral neck dissection may be recommended in PTC patients with those risk factors. Paying attention to the occurrence of skip lateral cervical lymph node metastasis during the clinical diagnosis and treatment processes is necessary.
摘要：
未经授权：探讨甲状腺乳头状癌（PTC）侧方淋巴结转移（LLNM）的危险因素。
UNASSIGNED：回顾性分析2014年11月至2018年11月在首都医科大学附属北京友谊医院接受原发性手术的209例PTC患者。将患者分为LLNM组和非LLNM组。分析患者的临床和病理特征。通过单因素和多因素分析LLNM的危险因素。
未经证实：PTC患者LLNM的发生率为13.4%。单因素分析显示原发肿瘤最大直径>2cm(P<0.001),双侧原发肿瘤（P=0.020），甲状腺外延伸（ETE）（P<0.001），中央区淋巴结转移(CLNM)(P<0.001),CLNM数≥5(P<0.001)与LLNM显著相关。多因素logistic回归分析显示原发肿瘤最大直径>2cm,ETE,和CLNM是LLNM的独立危险因素（OR值分别为3.880、5.202和4.474）。有6例跳过侧颈淋巴结转移，占所有LLNM患者的21%。
UNASSIGNED：这项研究揭示了预测PTC患者LLNM的几个独立危险因素，例如原发肿瘤的最大直径>2厘米，ETE和CLNM。对于具有这些危险因素的PTC患者，可能建议进行侧颈解剖。在临床诊断和治疗过程中，应注意跳过侧颈淋巴结转移的发生。
UNASSIGNED：回顾性分析2014年11月至2018年11月在首都医科大学附属北京友谊医院接受原发性手术的209例PTC患者。将患者分为LLNM组和非LLNM组。分析患者的临床和病理特征。通过单因素和多因素分析LLNM的危险因素。
未经证实：PTC患者LLNM的发生率为13.4%。单因素分析显示原发肿瘤最大直径>2cm(P<0.001),双侧原发肿瘤（P=0.020），甲状腺外延伸（ETE）（P<0.001），中央区淋巴结转移(CLNM)(P<0.001),CLNM数≥5(P<0.001)与LLNM显著相关。多因素logistic回归分析显示原发肿瘤最大直径>2cm,ETE,和CLNM是LLNM的独立危险因素（OR值分别为3.880、5.202和4.474）。有6例跳过侧颈淋巴结转移，占所有LLNM患者的21%。
UNASSIGNED：这项研究揭示了预测PTC患者LLNM的几个独立危险因素，例如原发肿瘤的最大直径>2厘米，ETE和CLNM。对于具有这些危险因素的PTC患者，可能建议进行侧颈解剖。在临床诊断和治疗过程中，应注意跳过侧颈淋巴结转移的发生。
