PDF(Pubmed)
Abstract：
Nutritional disorders have become a major public health issue, requiring increased targeted approaches. Personalized nutrition adapted to individual needs has garnered dramatic attention as an effective way to improve nutritional balance and maintain health. With the rapidly evolving fields of genomics and nutrigenetics, accumulation of genetic variants has been indicated to alter the effects of nutritional supplementation, suggesting its indispensable role in the genotype-based personalized nutrition. Additionally, the metabolism of nutrients, such as lipids, especially omega-3 polyunsaturated fatty acids, glucose, vitamin A, folic acid, vitamin D, iron, and calcium could be effectively improved with related genetic variants. This review focuses on existing literatures linking critical genetic variants to the nutrient and the ways in which these variants influence the outcomes of certain nutritional supplementations. Although further studies are required in this direction, such evidence provides valuable insights for the guidance of appropriate interventions using genetic information, thus paving the way for the smooth transition of conventional generic approach to genotype-based personalized nutrition.
摘要：
营养失调已成为主要的公共卫生问题,需要增加针对性的方法。适应个人需求的个性化营养作为改善营养平衡和保持健康的有效方法已经引起了极大的关注。随着基因组学和营养遗传学领域的快速发展，遗传变异的积累已被证明会改变营养补充的效果，提示其在基于基因型的个性化营养中不可或缺的作用。此外,营养物质的代谢，如脂质，尤其是omega-3多不饱和脂肪酸，葡萄糖，维生素A,叶酸,维生素D,铁,相关遗传变异可有效改善钙。这篇综述集中在现有文献中，将关键遗传变异与营养素联系起来，以及这些变异影响某些营养补充剂结果的方式。尽管在这个方向上需要进一步的研究，这些证据为使用遗传信息指导适当的干预措施提供了有价值的见解，从而为常规通用方法向基于基因型的个性化营养的平稳过渡铺平了道路。
