PDF(Pubmed)
Abstract：
BACKGROUND: Diffuse retinal pigment epitheliopathy (DRPE) associated with bullous retinal detachment is a severe variant of DRPE that is frequently misdiagnosed and often improperly treated.
METHODS: A 36-year-old female patient complained of \"painless vision decline in the left eye with obscuration for 10 d\". Slit-lamp microscopic fundus examination revealed white-yellow subretinal exudates in the posterior pole in both eyes, retinal detachment with shifting subretinal fluid in the left eye, and no retinal hiatus. Fundus fluorescein angiography revealed multiple subretinal leakage foci and localized hypofluorescent lesions with patched hyperfluorescence. There was fluorescence leakage in the retinal vessels in the retinal detachment area and occluded blood vessels in the lower and peripheral areas. Indocyanine green angiography revealed multifocal lamellar hyperfluorescence in the middle stage and low fluorescence in the retinal detachment area in the late stage. Retinal anatomical reduction significantly improved with intravitreal conbercept injections.
CONCLUSIONS: Intravitreal injection of conbercept can anatomically reattach the retina in patients with bullous retinal detachment.
METHODS: A 36-year-old female patient complained of \"painless vision decline in the left eye with obscuration for 10 d\". Slit-lamp microscopic fundus examination revealed white-yellow subretinal exudates in the posterior pole in both eyes, retinal detachment with shifting subretinal fluid in the left eye, and no retinal hiatus. Fundus fluorescein angiography revealed multiple subretinal leakage foci and localized hypofluorescent lesions with patched hyperfluorescence. There was fluorescence leakage in the retinal vessels in the retinal detachment area and occluded blood vessels in the lower and peripheral areas. Indocyanine green angiography revealed multifocal lamellar hyperfluorescence in the middle stage and low fluorescence in the retinal detachment area in the late stage. Retinal anatomical reduction significantly improved with intravitreal conbercept injections.
CONCLUSIONS: Intravitreal injection of conbercept can anatomically reattach the retina in patients with bullous retinal detachment.
摘要：
背景：与大疱性视网膜脱离相关的弥漫性视网膜色素上皮病（DRPE）是DRPE的严重变种，常被误诊，常被不当治疗。
方法：一名36岁女性患者主诉“左眼无痛性视力下降伴遮挡10d”。裂隙灯镜下眼底检查显示双眼后极有白色黄色视网膜下渗出物，左眼视网膜下液体移位的视网膜脱离,也没有视网膜裂孔.荧光素眼底血管造影显示多个视网膜下渗漏灶和局部低荧光性病变，并伴有补片的高荧光。视网膜脱离区域的视网膜血管中存在荧光泄漏，而下部和外围区域的血管阻塞。吲哚菁绿血管造影显示中期多灶性层状高荧光，晚期视网膜脱离区低荧光。玻璃体内康柏西普注射可显著改善视网膜解剖复位。
结论：玻璃体腔注射康柏西普可以使大疱性视网膜脱离患者的视网膜解剖复位。
方法：一名36岁女性患者主诉“左眼无痛性视力下降伴遮挡10d”。裂隙灯镜下眼底检查显示双眼后极有白色黄色视网膜下渗出物，左眼视网膜下液体移位的视网膜脱离,也没有视网膜裂孔.荧光素眼底血管造影显示多个视网膜下渗漏灶和局部低荧光性病变，并伴有补片的高荧光。视网膜脱离区域的视网膜血管中存在荧光泄漏，而下部和外围区域的血管阻塞。吲哚菁绿血管造影显示中期多灶性层状高荧光，晚期视网膜脱离区低荧光。玻璃体内康柏西普注射可显著改善视网膜解剖复位。
结论：玻璃体腔注射康柏西普可以使大疱性视网膜脱离患者的视网膜解剖复位。
