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Abstract：
UNASSIGNED: Biologic aggressiveness of OSCC (Oral Cavity Squamous Cell Carcinoma), has intrigued research in various prognosticating histopathological markers over past few decades. DOI (Depth of Invasion) is one such histopathological factor which affects outcomes and was included in the AJCC 8th edition TNM staging. Pattern of Invasion (POI) has been widely reported as an adverse prognostic factor associated with higher locoregional failure and poor prognosis. However, these factors are not utilized for treatment decision making and for outcome assessment.
UNASSIGNED: This is a retrospective analysis of 320 patients with OSCC who underwent treatment, from October 2018-February 2020. Clinic demographic details were extracted from electronic medical records. Univariate and multivariate analysis was done for the parameters. WPOI (Worst Pattern of Invasion) was correlated with all histopathological prognostic factors. Survival analysis was done using Kaplan Meier for WPOI type\'s I-V. DFS (Disease free Survival) was evaluated for different grades of WPOI.
UNASSIGNED: We analyzed the results comparing, early and advanced T (Tumor) stages, cohesive WPOI I-III, non-cohesive WPOI IV-V. Univariate analysis showed a significant association of T-stage (p = 0.001), N (Nodal) -stage (p = 0.002), DOI (p = 0.008), PNI (Peri-neural invasion) (0.001) and Tumor differentiation Grade (p = 0.001). On multivariate analysis, non-cohesive WPOI (IV & V) showed significant association with grade, PNI, DOI (0.002, 0.033 & 0.033 respectively). Non-cohesive WPOI had significantly higher locoregional failures and short DFS.
UNASSIGNED: Presence of invasive WPOI is associated with advanced T stage, poor differentiation, PNI, greater depth of invasion, and higher chances of nodal metastasis. WPOI is associated with poor DFS, treatment intensification in early stage disease with WPOI type IV & V may improve survival.
UNASSIGNED: This is a retrospective analysis of 320 patients with OSCC who underwent treatment, from October 2018-February 2020. Clinic demographic details were extracted from electronic medical records. Univariate and multivariate analysis was done for the parameters. WPOI (Worst Pattern of Invasion) was correlated with all histopathological prognostic factors. Survival analysis was done using Kaplan Meier for WPOI type\'s I-V. DFS (Disease free Survival) was evaluated for different grades of WPOI.
UNASSIGNED: We analyzed the results comparing, early and advanced T (Tumor) stages, cohesive WPOI I-III, non-cohesive WPOI IV-V. Univariate analysis showed a significant association of T-stage (p = 0.001), N (Nodal) -stage (p = 0.002), DOI (p = 0.008), PNI (Peri-neural invasion) (0.001) and Tumor differentiation Grade (p = 0.001). On multivariate analysis, non-cohesive WPOI (IV & V) showed significant association with grade, PNI, DOI (0.002, 0.033 & 0.033 respectively). Non-cohesive WPOI had significantly higher locoregional failures and short DFS.
UNASSIGNED: Presence of invasive WPOI is associated with advanced T stage, poor differentiation, PNI, greater depth of invasion, and higher chances of nodal metastasis. WPOI is associated with poor DFS, treatment intensification in early stage disease with WPOI type IV & V may improve survival.
摘要：
未经证实：OSCC（口腔鳞状细胞癌）的生物侵袭性，在过去的几十年中，人们对各种预测组织病理学标志物的研究很感兴趣。DOI（入侵深度）是一种影响结果的组织病理学因素，已包含在AJCC第8版TNM分期中。侵袭模式（POI）已被广泛报道为与较高的局部衰竭和不良预后相关的不良预后因素。然而,这些因素未用于治疗决策和结局评估.
UNASSIGNED：这是对接受治疗的320例OSCC患者的回顾性分析，从2018年10月至2020年2月。从电子病历中提取了诊所的人口统计详细信息。对参数进行单变量和多变量分析。WPOI（最差侵袭模式）与所有组织病理学预后因素相关。使用KaplanMeier对WPOI型I-V进行生存分析。对不同等级的WPOI评估DFS(无病存活)。
未经评估：我们分析了结果，早期和晚期T（肿瘤）阶段，有凝聚力的WPOII-III，非粘性WPOIIV-V单变量分析显示T分期显著相关(p=0.001)，N（节点）阶段（p=0.002），DOI（p=0.008），PNI（神经周浸润）（0.001）和肿瘤分化等级（p=0.001）。在多变量分析中，非粘性WPOI(IV&V)与年级显著相关，PNI,DOI（分别为0.002、0.033和0.033）。非粘性WPOI的局部区域故障和较短的DFS明显较高。
未经评估：侵入性WPOI的存在与晚期T期相关，分化差,PNI,更大的入侵深度，淋巴结转移的可能性更高。WPOI与糟糕的DFS相关，在WPOIIV和V型早期疾病中加强治疗可能会提高生存率。
UNASSIGNED：这是对接受治疗的320例OSCC患者的回顾性分析，从2018年10月至2020年2月。从电子病历中提取了诊所的人口统计详细信息。对参数进行单变量和多变量分析。WPOI（最差侵袭模式）与所有组织病理学预后因素相关。使用KaplanMeier对WPOI型I-V进行生存分析。对不同等级的WPOI评估DFS(无病存活)。
未经评估：我们分析了结果，早期和晚期T（肿瘤）阶段，有凝聚力的WPOII-III，非粘性WPOIIV-V单变量分析显示T分期显著相关(p=0.001)，N（节点）阶段（p=0.002），DOI（p=0.008），PNI（神经周浸润）（0.001）和肿瘤分化等级（p=0.001）。在多变量分析中，非粘性WPOI(IV&V)与年级显著相关，PNI,DOI（分别为0.002、0.033和0.033）。非粘性WPOI的局部区域故障和较短的DFS明显较高。
未经评估：侵入性WPOI的存在与晚期T期相关，分化差,PNI,更大的入侵深度，淋巴结转移的可能性更高。WPOI与糟糕的DFS相关，在WPOIIV和V型早期疾病中加强治疗可能会提高生存率。
