PDF(Pubmed)
Abstract：
Hemoglobin (Hb) and lipid metabolism are critical in the pathophysiology of moyamoya disease (MMD), and Hb and triglycerides (TGs) both play roles in the development of cerebrovascular illness. However, there is little evidence of a link between Hb and TGs in patients with MMD. This study aimed to determine the association between Hb and TGs in patients who had recently been diagnosed with MMD. From March 2013 to December 2018, 337 patients clinically diagnosed with MMD were admitted to our hospital. Among these, 235 were selected for analysis in this retrospective, cross-sectional study. Each patient\'s clinical features were documented. For analysis, we used univariate analysis, smoothed-curve fitting, and multivariable, piecewise linear regression. Overall, the mean±standard deviation patient age was 48.14 ± 11.24 years, 44.68% were men, and the mean Hb concentration was 135.72 ± 18.99 g/L. After controlling for relevant confounders, smoothed-curve fitting revealed a nonlinear association between the Hb and TG concentrations (P = 0.0448). When the Hb concentration was below 141 g/L, multivariate piecewise linear regression analysis revealed a significant association between the Hb and TG concentrations [β: 0.01, 95% confidence interval (CI): 0.00, 0.01; P = 0.0182], although the association disappeared above this threshold (β:-0.00, 95% CI:-0.01, 0.01; P = 0.4429). In individuals newly diagnosed with MMD, there is a significant correlation between Hb and TGs, which may be connected to MMD pathogenesis.
摘要：
血红蛋白（Hb）和脂质代谢在烟雾病（MMD）的病理生理学中至关重要，Hb和甘油三酯（TG）都在脑血管疾病的发展中起作用。然而,几乎没有证据表明MMD患者的Hb和TGs之间存在联系.这项研究旨在确定最近被诊断为MMD的患者中Hb和TG之间的关联。2013年3月至2018年12月，我院收治临床诊断为MMD的337例患者。其中,在这项回顾性研究中，选择了235人进行分析，横断面研究。记录每位患者的临床特征。为了进行分析，我们使用单变量分析，平滑曲线拟合，和多变量，分段线性回归。总的来说,平均±标准差患者年龄为48.14±11.24岁，44.68%是男性，平均Hb浓度为135.72±18.99g/L在控制了相关的混杂因素后，平滑曲线拟合显示Hb和TG浓度之间存在非线性关联(P=0.0448)。当Hb浓度低于141g/L时，多元分段线性回归分析显示Hb和TG浓度之间存在显着关联[β：0.01，95％置信区间（CI）：0.00，0.01；P=0.0182]，尽管该关联在该阈值以上消失（β：-0.00，95％CI：-0.01，0.01；P=0.4429）。在新诊断为MMD的个体中，Hb和TG之间存在显著的相关性，这可能与MMD发病机制有关。
