关键词: TMS cortical stroke fMRI hyaluronic acid filler rehabilitation

来  源:   DOI:10.3389/fneur.2022.903648   PDF(Pubmed)

Abstract:
UNASSIGNED: Blindness and stroke resulting from hyaluronic acid (HA) fillers are not frequently reported complications. Reports on stroke recovery after HA injection are limited. In the current study, the recovery process, task-based functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and neurophysiological changes of a patient with monocular blindness and ipsilateral motor cortical stroke after forehead injection of HA are explored.
UNASSIGNED: The study comprised a 34-year-old female patient who presented with left eye blindness and a stroke after receiving an HA injection a month before admission. The lesion was mainly limited to the left precentral gyrus, and the patient had pure arm monoparesis. For 3 weeks, the patient received conventional rehabilitation treatments and ten sessions of repetitive transcranial magnetic stimulation (rTMS) intervention. Clinical assessments, neurophysiological evaluation, task-based fMRI, and DTI examinations were conducted to assess her motor improvement and the possible neuro mechanism.
UNASSIGNED: The patient\'s right upper limb motor function was almost completely restored after receiving rehabilitation therapy. However, the vision in her left eye did not show significant improvement. The neurophysiological evaluation showed partial recovery of the ipsilesional motor evoked potentials (MEPs). DTI results showed that the ipsilesional corticospinal tract (CST) was intact. Task-based fMRI results indicated that the activation pattern of the affected hand movement was gradually restored to normal.
UNASSIGNED: A case of good motor recovery after stroke due to HA injection with a lesion mainly restricted to the precentral gyrus but without CST damage is presented in the current study. Further studies should be conducted to explore the efficacy and the mechanisms of rehabilitation and neuromodulation approaches to motor cortical stroke.
摘要:
未经证实:由透明质酸(HA)填充剂引起的失明和中风不是经常报告的并发症。关于注射HA后中风恢复的报告有限。在目前的研究中,恢复过程,基于任务的功能磁共振成像(fMRI),扩散张量成像(DTI),探讨了单眼盲和同侧运动性皮质卒中患者在前额注射HA后的神经生理变化。
UNASSIGNED:该研究包括一名34岁女性患者,在入院前一个月接受HA注射后出现左眼失明和中风。病变主要局限于左中央前回,患者有纯手臂单瘫.三个星期,患者接受常规康复治疗和十次重复经颅磁刺激(rTMS)干预.临床评估,神经生理学评估,基于任务的功能磁共振成像,进行DTI检查以评估她的运动改善和可能的神经机制。
UNASSIGNED:患者的右上肢运动功能在接受康复治疗后几乎完全恢复。然而,她的左眼视力没有显著改善.神经生理学评估显示,同病运动诱发电位(MEP)部分恢复。DTI结果显示,皮损皮质脊髓束(CST)完好无损。基于任务的fMRI结果表明,受影响的手部运动的激活模式逐渐恢复正常。
UNASSIGNED:本研究中介绍了一例由于注射HA引起的卒中后运动恢复良好的病例,病变主要局限于中央前回,但没有CST损伤。应进行进一步的研究,以探索康复和神经调节方法对运动皮质中风的功效和机制。
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