PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to study the role of PALB2 on the prognosis of skull base chordoma patients and the proliferation, migration, and invasion of chordoma cells.
UNASSIGNED: 187 patients with primary skull base chordoma were involved in the study. Immunohistochemical analysis was used to measure the PALB2 protein expression. Kaplan-Meier analysis, univariate and multivariate Cox analysis were used to evaluate the impact of PALB2 on patient prognosis. A nomogram was established for predicting the progression free survival of chordoma patients. Cell counting kit-8, colony formation, transwell migration, and invasion assays were used to assess the proliferation, migration, and invasion of chordoma cells with PALB2 knockdown. TIMER 2.0 was used to explore the expression and prognostic role of PALB2 in cancers.
UNASSIGNED: High PALB2 expression indicated an adverse prognosis in chordoma. A nomogram involved PALB2, degree of resection, pathology, and Al-mefty classification could accurately predict the progression free survival of chordoma patients. The proliferation, migration, and invasion of chordoma cells significantly decreased after PALB2 knockdown. Additionally, PALB2 showed high expression in various cancers and was associated with a poor prognosis.
UNASSIGNED: In summary, our results reveal that high PALB2 expression indicates a poor prognosis of chordoma patients and promotes the malignant phenotypes of chordoma cells in vitro.
UNASSIGNED: 187 patients with primary skull base chordoma were involved in the study. Immunohistochemical analysis was used to measure the PALB2 protein expression. Kaplan-Meier analysis, univariate and multivariate Cox analysis were used to evaluate the impact of PALB2 on patient prognosis. A nomogram was established for predicting the progression free survival of chordoma patients. Cell counting kit-8, colony formation, transwell migration, and invasion assays were used to assess the proliferation, migration, and invasion of chordoma cells with PALB2 knockdown. TIMER 2.0 was used to explore the expression and prognostic role of PALB2 in cancers.
UNASSIGNED: High PALB2 expression indicated an adverse prognosis in chordoma. A nomogram involved PALB2, degree of resection, pathology, and Al-mefty classification could accurately predict the progression free survival of chordoma patients. The proliferation, migration, and invasion of chordoma cells significantly decreased after PALB2 knockdown. Additionally, PALB2 showed high expression in various cancers and was associated with a poor prognosis.
UNASSIGNED: In summary, our results reveal that high PALB2 expression indicates a poor prognosis of chordoma patients and promotes the malignant phenotypes of chordoma cells in vitro.
摘要：
UNASSIGNED：本研究旨在研究PALB2对颅底脊索瘤患者预后和增殖的作用，迁移,和脊索瘤细胞的侵袭。
UNASSIGNED：187例原发性颅底脊索瘤患者参与了这项研究。免疫组织化学分析用于测量PALB2蛋白表达。Kaplan-Meier分析,采用单因素和多因素Cox分析评估PALB2对患者预后的影响.建立了用于预测脊索瘤患者无进展生存期的列线图。细胞计数试剂盒-8，集落形成，Transwell迁移,和侵袭试验用于评估增殖，迁移,与PALB2敲除的脊索瘤细胞的侵袭。TIMER2.0用于探讨PALB2在癌症中的表达和预后作用。
未经证实：高PALB2表达提示脊索瘤预后不良。列线图涉及PALB2，切除程度，病理学,Al-mefty分类可以准确预测脊索瘤患者的无进展生存期。扩散,迁移,PALB2敲除后脊索瘤细胞的侵袭能力明显下降。此外,PALB2在各种癌症中显示高表达，并与不良预后相关。
未经评估：总之，我们的结果表明，高表达PALB2表明脊索瘤患者的预后不良，并促进了脊索瘤细胞的恶性表型。
UNASSIGNED：187例原发性颅底脊索瘤患者参与了这项研究。免疫组织化学分析用于测量PALB2蛋白表达。Kaplan-Meier分析,采用单因素和多因素Cox分析评估PALB2对患者预后的影响.建立了用于预测脊索瘤患者无进展生存期的列线图。细胞计数试剂盒-8，集落形成，Transwell迁移,和侵袭试验用于评估增殖，迁移,与PALB2敲除的脊索瘤细胞的侵袭。TIMER2.0用于探讨PALB2在癌症中的表达和预后作用。
未经证实：高PALB2表达提示脊索瘤预后不良。列线图涉及PALB2，切除程度，病理学,Al-mefty分类可以准确预测脊索瘤患者的无进展生存期。扩散,迁移,PALB2敲除后脊索瘤细胞的侵袭能力明显下降。此外,PALB2在各种癌症中显示高表达，并与不良预后相关。
未经评估：总之，我们的结果表明，高表达PALB2表明脊索瘤患者的预后不良，并促进了脊索瘤细胞的恶性表型。
