PDF(Pubmed)
Abstract：
UNASSIGNED: Recurrent or de novo nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common after liver transplantation (LT) and may be associated with rapid progression to fibrosis; however, there is limited data in this regard after living donor liver transplantation (LDLT).
UNASSIGNED: This is a retrospective study at a high volume LDLT center of all liver biopsies performed in patients with post-transplant NAFLD diagnosed on ultrasound of the abdomen. Liver biopsy was indicated for raised transaminases and/or high liver stiffness on TE. The association between these prebiopsy parameters and inflammation and fibrosis on histology was analyzed. Data are shown as mean ± standard deviation or median (25-75 interquartile range).
UNASSIGNED: The study cohort consisted of 31 males and 3 females, aged 43 ± 10 years. The LT to liver biopsy interval was 44 (28-68) months. The prebiopsy AST and ALT were 71 (38-119) and 66 (50-156), respectively. The histology suggested no nonalcoholic steatohepatitis (NASH) in 7 (20%), borderline NASH in 15 (44%), and NASH in 12 (35%) patients. A total of 15 patients (44%) had stage 1 or stage 2 fibrosis. The proportion of patients having fibrosis was significantly higher in patients with NASH (83%) compared to patients with borderline NASH (33%) or no NASH (none had fibrosis, P = 0.001). Among 18 patients who underwent TE (on FibroScan), liver stiffness was significantly higher in patients with fibrosis [18.1 (9.7-22.5)] than in those without fibrosis [9.7 (4.0-12.7); P = 0.043].
UNASSIGNED: Over a third of the LDLT recipients with post-transplant NAFLD developed NASH, and nearly half, borderline NASH 3-5 years after transplant. Most with established NASH also had fibrosis on histology. Prevention of risk factors and early diagnosis is warranted in these patients.
UNASSIGNED: This is a retrospective study at a high volume LDLT center of all liver biopsies performed in patients with post-transplant NAFLD diagnosed on ultrasound of the abdomen. Liver biopsy was indicated for raised transaminases and/or high liver stiffness on TE. The association between these prebiopsy parameters and inflammation and fibrosis on histology was analyzed. Data are shown as mean ± standard deviation or median (25-75 interquartile range).
UNASSIGNED: The study cohort consisted of 31 males and 3 females, aged 43 ± 10 years. The LT to liver biopsy interval was 44 (28-68) months. The prebiopsy AST and ALT were 71 (38-119) and 66 (50-156), respectively. The histology suggested no nonalcoholic steatohepatitis (NASH) in 7 (20%), borderline NASH in 15 (44%), and NASH in 12 (35%) patients. A total of 15 patients (44%) had stage 1 or stage 2 fibrosis. The proportion of patients having fibrosis was significantly higher in patients with NASH (83%) compared to patients with borderline NASH (33%) or no NASH (none had fibrosis, P = 0.001). Among 18 patients who underwent TE (on FibroScan), liver stiffness was significantly higher in patients with fibrosis [18.1 (9.7-22.5)] than in those without fibrosis [9.7 (4.0-12.7); P = 0.043].
UNASSIGNED: Over a third of the LDLT recipients with post-transplant NAFLD developed NASH, and nearly half, borderline NASH 3-5 years after transplant. Most with established NASH also had fibrosis on histology. Prevention of risk factors and early diagnosis is warranted in these patients.
摘要：
UNASSIGNED:复发性或从头非酒精性脂肪性肝病(NAFLD)和非酒精性脂肪性肝炎(NASH)在肝移植(LT)后很常见，可能与纤维化的快速进展有关；然而，活体肝移植(LDLT)后这方面的数据有限.
UNASSIGNED：这是一项回顾性研究，在一个高容量LDLT中心对腹部超声诊断的移植后NAFLD患者进行的所有肝活检。在TE上，肝活检表明转氨酶升高和/或肝硬度高。分析了这些活检前参数与组织学上的炎症和纤维化之间的关联。数据显示为平均值±标准偏差或中值(25-75四分位数范围)。
未经评估：研究队列包括31名男性和3名女性，年龄43±10岁。LT到肝活检间隔为44（28-68）个月。活检前AST和ALT分别为71（38-119）和66（50-156），分别。组织学提示7例（20％）没有非酒精性脂肪性肝炎（NASH），临界NASH在15（44%），12例（35%）患者的NASH。共有15名患者（44％）患有1期或2期纤维化。NASH患者（83％）的纤维化患者比例明显高于临界NASH患者（33％）或无NASH患者（均无纤维化，P=0.001)。在18例接受TE的患者中（在FibroScan上），纤维化患者的肝硬度[18.1(9.7-22.5)]显著高于无纤维化患者[9.7(4.0-12.7);P=0.043].
未经证实：移植后NAFLD的LDLT受者中有三分之一发展为NASH，近一半，移植后3-5年的NASH边界。大多数已建立的NASH在组织学上也具有纤维化。这些患者需要预防危险因素和早期诊断。
UNASSIGNED：这是一项回顾性研究，在一个高容量LDLT中心对腹部超声诊断的移植后NAFLD患者进行的所有肝活检。在TE上，肝活检表明转氨酶升高和/或肝硬度高。分析了这些活检前参数与组织学上的炎症和纤维化之间的关联。数据显示为平均值±标准偏差或中值(25-75四分位数范围)。
未经评估：研究队列包括31名男性和3名女性，年龄43±10岁。LT到肝活检间隔为44（28-68）个月。活检前AST和ALT分别为71（38-119）和66（50-156），分别。组织学提示7例（20％）没有非酒精性脂肪性肝炎（NASH），临界NASH在15（44%），12例（35%）患者的NASH。共有15名患者（44％）患有1期或2期纤维化。NASH患者（83％）的纤维化患者比例明显高于临界NASH患者（33％）或无NASH患者（均无纤维化，P=0.001)。在18例接受TE的患者中（在FibroScan上），纤维化患者的肝硬度[18.1(9.7-22.5)]显著高于无纤维化患者[9.7(4.0-12.7);P=0.043].
未经证实：移植后NAFLD的LDLT受者中有三分之一发展为NASH，近一半，移植后3-5年的NASH边界。大多数已建立的NASH在组织学上也具有纤维化。这些患者需要预防危险因素和早期诊断。
