Abstract：
The chromatin dispersion test (CDT) is based on the removal of nuclear proteins under the assumption that cells with fragmented DNA produce a typical halo of circular DNA loops, which is absent in cells with non-fragmented DNA. This method represents a simple, rapid, accurate, highly reproducible, and inexpensive technique to assess nuclear DNA damage in somatic cells. The visualization of DNA damage and the capacity of the test to provide a threshold value to discriminate between high and low levels of cervical lesions would aid in determining the malignant transformation. All of these advantages associated with the CDT protocol could promote this technique as a tool for the quick and reliable diagnosis of cervical epithelial disorders, even at primary-care centers.
摘要：
染色质色散测试（CDT）是基于去除核蛋白的假设，即具有片段化DNA的细胞产生典型的环状DNA环的光环，在具有非片段化DNA的细胞中不存在。此方法表示一个简单的,快速,准确,高度可重复,以及评估体细胞中核DNA损伤的廉价技术。DNA损伤的可视化和提供区分高水平和低水平宫颈病变的阈值的测试能力将有助于确定恶性转化。与CDT协议相关的所有这些优点可以促进这种技术作为快速可靠诊断宫颈上皮疾病的工具，甚至在初级保健中心。
