Abstract：
OBJECTIVE: To use quantitative MRI to assess gender differences in lateral pterygoid muscle (LPM) characteristics in patients with anterior disk displacement (ADD).
METHODS: Lateral pterygoid muscle of 51 patients diagnosed with temporomandibular joint disorders (TMD) who underwent T1-weighted Dixon and T1-mapping sequences were retrospectively analyzed. There were 34 female patients (10 with bilateral normal position disk [NP]; 24 with bilateral ADD) and 17 male patients (eight with bilateral NP; nine with bilateral ADD) among them. After controlling for age, differences in fat fraction, T1 value, volume and histogram features related to gender and disk status were tested with 2-way ANCOVA or Quade ANCOVA with Bonferroni correction.
RESULTS: Volume of LPM in NP was significantly smaller than that of ADD (p < 0.001). Fat fraction of LPM in females with NP was significantly higher than males with NP (p < 0.05). Females with ADD showed a significantly higher T1 value (p < 0.05), and higher intramuscular heterogeneity than males with ADD.
CONCLUSIONS: Lateral pterygoid muscle in female TMD patients presented more fatty infiltration in the NP stage and might present more fibrosis in the ADD stage compared with males. Together, this leads to more serious intramuscular heterogeneity during the pathogenesis of ADD in females.
METHODS: Lateral pterygoid muscle of 51 patients diagnosed with temporomandibular joint disorders (TMD) who underwent T1-weighted Dixon and T1-mapping sequences were retrospectively analyzed. There were 34 female patients (10 with bilateral normal position disk [NP]; 24 with bilateral ADD) and 17 male patients (eight with bilateral NP; nine with bilateral ADD) among them. After controlling for age, differences in fat fraction, T1 value, volume and histogram features related to gender and disk status were tested with 2-way ANCOVA or Quade ANCOVA with Bonferroni correction.
RESULTS: Volume of LPM in NP was significantly smaller than that of ADD (p < 0.001). Fat fraction of LPM in females with NP was significantly higher than males with NP (p < 0.05). Females with ADD showed a significantly higher T1 value (p < 0.05), and higher intramuscular heterogeneity than males with ADD.
CONCLUSIONS: Lateral pterygoid muscle in female TMD patients presented more fatty infiltration in the NP stage and might present more fibrosis in the ADD stage compared with males. Together, this leads to more serious intramuscular heterogeneity during the pathogenesis of ADD in females.
摘要：
目的：使用定量MRI评估前椎间盘移位（ADD）患者翼外肌（LPM）特征的性别差异。
方法：回顾性分析51例诊断为颞下颌关节紊乱病（TMD）并接受T1加权Dixon和T1作图序列的患者的翼外肌。其中女性患者34例（双侧正常位置盘[NP]10例；双侧ADD24例）和男性患者17例（双侧NP8例；双侧ADD9例）。在控制了年龄之后,脂肪分数的差异，T1值,采用双向ANCOVA或QuadeANCOVA结合Bonferroni校正检测与性别和椎间盘状态相关的体积和直方图特征.
结果：NP中LPM的体积明显小于ADD（p<0.001）。NP女性的LPM脂肪分数显著高于NP男性(p<0.05)。患有ADD的女性表现出明显更高的T1值(p<0.05)，肌肉内异质性高于男性ADD。
结论：与男性相比，女性TMD患者的翼外肌在NP期表现出更多的脂肪浸润，在ADD期可能表现出更多的纤维化。一起,这导致女性ADD发病过程中更严重的肌内异质性。
方法：回顾性分析51例诊断为颞下颌关节紊乱病（TMD）并接受T1加权Dixon和T1作图序列的患者的翼外肌。其中女性患者34例（双侧正常位置盘[NP]10例；双侧ADD24例）和男性患者17例（双侧NP8例；双侧ADD9例）。在控制了年龄之后,脂肪分数的差异，T1值,采用双向ANCOVA或QuadeANCOVA结合Bonferroni校正检测与性别和椎间盘状态相关的体积和直方图特征.
结果：NP中LPM的体积明显小于ADD（p<0.001）。NP女性的LPM脂肪分数显著高于NP男性(p<0.05)。患有ADD的女性表现出明显更高的T1值(p<0.05)，肌肉内异质性高于男性ADD。
结论：与男性相比，女性TMD患者的翼外肌在NP期表现出更多的脂肪浸润，在ADD期可能表现出更多的纤维化。一起,这导致女性ADD发病过程中更严重的肌内异质性。
