Abstract：
BACKGROUND: Cerebrospinal fluid (CSF) is commonly analyzed in South American camelids with suspected neurologic disease because of ease of collection and characteristic findings associated with certain diseases.
OBJECTIVE: To assess CSF findings associated with short-term survival or non-survival in South American camelids in which neurologic disease was a differential diagnosis based on history and physical examination.
METHODS: Twenty-one llamas and 33 alpacas that underwent CSF analysis at the University of Missouri Veterinary Health Center.
METHODS: Retrospective study. Medical records of camelids that underwent CSF analysis between January 2005 and September 2021 were studied. Short-term survival was defined as survival to discharge from the Veterinary Health Center. A Fisher\'s exact test was used to compare species, CSF results, and survival.
RESULTS: Odds of survival were 3.9 times higher in camelids with a total nucleated cell count (TNCC) <3 cells/μL (P = .04). No significant association was found between survival and total protein concentration (TPC; P = .15) or percentage of eosinophils (P = 1.0). No significant correlation was found between species and increased TNCC (P = .63), TPC (P = .55), or percentage of eosinophils (P = .30). Among camelids diagnosed with Paralephostrongylus tenuis infestation, odds of survival were 4.95 times higher in alpacas (P = .05).
CONCLUSIONS: Cerebrospinal fluid TNCC ≥3 cells/μL is associated with decreased odds of short-term survival in South American camelids.
OBJECTIVE: To assess CSF findings associated with short-term survival or non-survival in South American camelids in which neurologic disease was a differential diagnosis based on history and physical examination.
METHODS: Twenty-one llamas and 33 alpacas that underwent CSF analysis at the University of Missouri Veterinary Health Center.
METHODS: Retrospective study. Medical records of camelids that underwent CSF analysis between January 2005 and September 2021 were studied. Short-term survival was defined as survival to discharge from the Veterinary Health Center. A Fisher\'s exact test was used to compare species, CSF results, and survival.
RESULTS: Odds of survival were 3.9 times higher in camelids with a total nucleated cell count (TNCC) <3 cells/μL (P = .04). No significant association was found between survival and total protein concentration (TPC; P = .15) or percentage of eosinophils (P = 1.0). No significant correlation was found between species and increased TNCC (P = .63), TPC (P = .55), or percentage of eosinophils (P = .30). Among camelids diagnosed with Paralephostrongylus tenuis infestation, odds of survival were 4.95 times higher in alpacas (P = .05).
CONCLUSIONS: Cerebrospinal fluid TNCC ≥3 cells/μL is associated with decreased odds of short-term survival in South American camelids.
摘要：
背景：由于易于收集和与某些疾病相关的特征性发现，通常在疑似神经系统疾病的南美骆驼中分析脑脊液（CSF）。
目的：评估与南美骆驼短期生存或非生存相关的CSF发现，其中神经系统疾病是基于病史和体格检查的鉴别诊断。
方法：在密苏里大学兽医健康中心接受CSF分析的21只美洲驼和33只羊驼。
方法：回顾性研究。研究了2005年1月至2021年9月期间接受CSF分析的骆驼科的医疗记录。短期生存率定义为从兽医健康中心出院后的生存率。费舍尔的精确检验被用来比较物种，CSF结果，和生存。
结果：有核细胞总数（TNCC）<3个细胞/μL的骆驼科动物的存活几率高出3.9倍（P=0.04）。生存率与总蛋白浓度（TPC；P=.15）或嗜酸性粒细胞百分比（P=1.0）之间没有显着关联。在物种和TNCC增加之间没有发现显著的相关性(P=.63)，TPC（P=.55），或嗜酸性粒细胞百分比（P=0.30）。在被诊断出患有肌腱副孢子虫感染的骆驼中，羊驼的生存几率高4.95倍（P=0.05）。
结论：脑脊液TNCC≥3细胞/μL与南美骆驼短期生存几率降低相关。
目的：评估与南美骆驼短期生存或非生存相关的CSF发现，其中神经系统疾病是基于病史和体格检查的鉴别诊断。
方法：在密苏里大学兽医健康中心接受CSF分析的21只美洲驼和33只羊驼。
方法：回顾性研究。研究了2005年1月至2021年9月期间接受CSF分析的骆驼科的医疗记录。短期生存率定义为从兽医健康中心出院后的生存率。费舍尔的精确检验被用来比较物种，CSF结果，和生存。
结果：有核细胞总数（TNCC）<3个细胞/μL的骆驼科动物的存活几率高出3.9倍（P=0.04）。生存率与总蛋白浓度（TPC；P=.15）或嗜酸性粒细胞百分比（P=1.0）之间没有显着关联。在物种和TNCC增加之间没有发现显著的相关性(P=.63)，TPC（P=.55），或嗜酸性粒细胞百分比（P=0.30）。在被诊断出患有肌腱副孢子虫感染的骆驼中，羊驼的生存几率高4.95倍（P=0.05）。
结论：脑脊液TNCC≥3细胞/μL与南美骆驼短期生存几率降低相关。
