Abstract：
This study focuses on spina bifida, which is a high incidence among the current clinical manifestations of human birth defects. Because in the treatment of bone defects, the source of autologous bone is limited and it is easy to cause secondary injury to the patient. At the same time, since the bone tissue in animals needs to perform a variety of biological functions, its complex structure cannot be replaced by a single material. Therefore, in this study, we used Japanese white rabbits to establish an animal model similar to human congenital spina bifida. The established animal model is used to screen the best regenerative repair products for the treatment of congenital spondylolisthesis defects, and to evaluate the safety of regenerative repair products. The results show that bone morphogenetic protein (BMP)-2 combined with collagen material has a better regeneration effect than collagen material alone, and it did not negatively affect the health of animals. This study is not only suitable for the screening of large-scale biomaterials, accelerating the research progress of regenerative repair products, but also conducive to the research on the mechanism of regeneration and repair of various materials.
摘要：
这项研究的重点是脊柱裂，这是目前人类出生缺陷临床表现中的高发。因为在骨缺损的治疗中，自体骨来源有限，容易对患者造成二次损伤。同时,由于动物的骨组织需要执行各种生物学功能，其复杂的结构是单一材料所不能替代的。因此,在这项研究中，我们用日本大白兔建立了类似于人类先天性脊柱裂的动物模型。利用所建立的动物模型筛选出治疗先天性腰椎滑脱缺损的最佳再生修复产品,评估再生修复产品的安全性。结果表明,骨形态发生蛋白(BMP)-2与胶原质材料结合比单独使用胶原质材料具有更好的再生效果,它没有对动物的健康产生负面影响。本研究不仅适用于大规模生物材料的筛选,加快再生修复产品的研究进展，也有利于对各种材料的再生和修复机理的研究。
