Abstract：
Blueberries represent a rich source of (poly)phenols and other bioactive compounds. Numerous in vitro and animal model studies documented the potential health-promoting properties of blueberries and blueberry-bioactives, while little is still known about their effects in humans. The objective of the present systematic review is to provide main evidence and the potential mechanisms of action of blueberry and its (poly)phenols in the regulation of markers related to oxidative stress, inflammation, vascular and cardiometabolic function in health and disease states. A total of 45 human intervention studies were included in this review. Overall, the evidence suggests that blueberries may play a role in the improvement of markers of vascular function. Their effects were observed following both post-prandial and long-term consumption, particularly in subjects with risk factors and/or disease conditions. Conversely, the conflicting results on inflammation, oxidative stress and cardiometabolic risk markers were most likely due to differences among studies in terms of study design, subject characteristics, duration of intervention, dosage, and type of biomarkers analyzed. For these reasons, high-quality, well-designed, human intervention studies are warranted to strengthen the current findings on vascular function and provide more evidence about the impact of blueberries on the different markers considered. In addition, studies focusing on the relationship between the structure and the function of (poly)phenols will be fundamental for a better comprehension of the mechanisms behind the health effects observed.
摘要：
蓝莓代表了(多)酚和其他生物活性化合物的丰富来源。许多体外和动物模型研究记录了蓝莓和蓝莓生物活性物质的潜在健康促进特性，虽然对它们对人类的影响知之甚少。本系统综述的目的是提供蓝莓及其（聚）酚在氧化应激相关标志物调控中的主要证据和潜在作用机制。炎症,健康和疾病状态下的血管和心脏代谢功能。本综述共纳入45项人类干预研究。总的来说,证据表明，蓝莓可能在改善血管功能标志物中发挥作用。在餐后和长期食用后观察到它们的效果，特别是在具有风险因素和/或疾病状况的受试者中。相反，关于炎症的相互矛盾的结果，氧化应激和心脏代谢风险标志物最有可能是由于研究设计方面的研究之间的差异，主题特征,干预的持续时间，剂量,并分析了生物标志物的类型。由于这些原因,高品质，精心设计,人类干预研究有必要加强目前对血管功能的发现,并提供更多关于蓝莓对所考虑的不同标志物的影响的证据.此外,关注（聚）酚的结构和功能之间的关系的研究将是更好地理解所观察到的健康影响背后的机制的基础。
