Abstract：
In 1967, Andén, Fuxe, and Ungerstedt demonstrated the presence of monoamine-containing fibers in the rat cerebellum. Over the past 50 years, this finding has provided clinical relevance of the noradrenergic system to the cerebellum. Cerebellar dysfunction and noradrenergic system may relate to tremor in Parkinson disease and essential tremor, motor learning, and the vestibulo-ocular reflex in spinocerebellar ataxias. Cognition and emotion may also be linked to the cerebellar noradrenergic system, in relation to the symptoms of Alzheimer disease, dementia with Lewy bodies, and attention-deficit/hyperactivity disorder. Despite recent technological advances in neuroimaging for evaluating the noradrenergic system, we need more evidence to understand the precise pathophysiological relationship between the cerebellum and the noradrenergic system and its clinical implications.
摘要：
1967年安登,Fuxe,Ungerstedt证明了大鼠小脑中存在含单胺的纤维。在过去的50年里,这一发现提供了去甲肾上腺素能系统与小脑的临床相关性.小脑功能障碍和去甲肾上腺素能系统可能与帕金森病和特发性震颤的震颤有关。运动学习,和脊髓小脑共济失调的前庭眼反射。认知和情绪也可能与小脑去甲肾上腺素能系统有关，关于阿尔茨海默病的症状，路易体痴呆症，和注意力缺陷/多动障碍。尽管最近在评估去甲肾上腺素能系统的神经影像学技术上取得了进步，我们需要更多的证据来了解小脑与去甲肾上腺素能系统之间的精确病理生理关系及其临床意义。
