Abstract：
With osteoarthritis being the most common degenerative disease in pet animals, a very broad panel of natural health products is available on the market for its management. The aim of this systematic review and meta-analysis, registered on PROSPERO (CRD42021279368), was to test for the evidence of clinical analgesia efficacy of fortified foods and nutraceuticals administered in dogs and cats affected by osteoarthritis. In four electronic bibliographic databases, 1578 publications were retrieved plus 20 additional publications from internal sources. Fifty-seven articles were included, comprising 72 trials divided into nine different categories of natural health compound. The efficacy assessment, associated to the level of quality of each trial, presented an evident clinical analgesic efficacy for omega-3-enriched diets, omega-3 supplements and cannabidiol (to a lesser degree). Our analyses showed a weak efficacy of collagen and a very marked non-effect of chondroitin-glucosamine nutraceuticals, which leads us to recommend that the latter products should no longer be recommended for pain management in canine and feline osteoarthritis.
摘要：
骨关节炎是宠物动物最常见的退行性疾病，市场上有一个非常广泛的天然健康产品小组，用于其管理。本系统综述和荟萃分析的目的是，在PROSPERO(CRD42021279368)上注册，是为了测试强化食品和营养食品在受骨关节炎影响的狗和猫中的临床镇痛效果的证据。在四个电子书目数据库中，从内部来源检索了1578种出版物以及20种其他出版物。包括57篇文章，包括72个试验，分为9个不同类别的天然健康化合物。疗效评估，与每个试验的质量水平相关，对富含omega-3的饮食有明显的临床镇痛效果，omega-3补充剂和大麻二酚（程度较低）。我们的分析表明胶原蛋白的功效较弱，软骨素-葡糖胺营养保健品的效果非常明显，这导致我们建议不再推荐后者产品用于犬科和猫科动物骨关节炎的疼痛管理。
