A between-subject, cross-sectional experimental design was adopted. Serum levels of TNF-α, IL-6, IL-12, IL-23, IFN-γ, IL-17, IL-10, Gal-3, and WOMAC score were measured.
Gonarthrosis patients with diabetes mellitus had significantly (p < 0.05) lower levels of TNF-α, IL-6, IL-12, IL-17, IFN-γ, and Gal-3 compared to gonarthrosis patients without diabetes mellitus. On the other hand, IL-10/TNF-α, IL-10/IL-6, IL-10/IL-12, Gal-3/TNF-α, Gal-3/IL-6, and Gal-3/IL-12 (p = 0.001) were significantly higher (p < 0.05) in gonarthrosis with diabetes mellitus. Moderate-large correlation (p < 0.05) was detected between the serum values of Gal-3 and pro- and anti-inflammatory cytokines, including IL-12 (r = 0.575), IL-10 (r = 0.535), TNF-α (r = 0.306), and IL-23 (r = 0.323). WOMAC index was significantly lower (p < 0.05) in gonarthrosis patients without diabetes mellitus compared to gonarthrosis patients with diabetes mellitus.
Correlation between Gal-3 and proinflammatory cytokines and its dominance over proinflammatory cytokines implicate the potential role of Gal-3 in preventing cartilage destruction.
主题之间,采用横断面实验设计。血清TNF-α水平,IL-6,IL-12,IL-23,IFN-γ,测量IL-17、IL-10、Gal-3和WOMAC评分。
合并糖尿病的关节炎患者的TNF-α水平显著降低(p<0.05),IL-6,IL-12,IL-17,IFN-γ,和Gal-3与无糖尿病的膝关节病患者相比。另一方面,IL-10/TNF-α,IL-10/IL-6,IL-10/IL-12,Gal-3/TNF-α,Gal-3/IL-6和Gal-3/IL-12(p=0.001)在糖尿病性关节炎中明显更高(p<0.05)。检测到Gal-3与促炎和抗炎细胞因子的血清值之间存在中等大相关性(p<0.05),包括IL-12(r=0.575),IL-10(r=0.535),TNF-α(r=0.306),IL-23(r=0.323)。与糖尿病性关节炎患者相比,无糖尿病性关节炎患者的WOMAC指数显着降低(p<0.05)。
Gal-3与促炎细胞因子之间的相关性及其对促炎细胞因子的优势暗示了Gal-3在预防软骨破坏中的潜在作用。