Abstract：
Gonarthrosis and diabetes mellitus are two diseases that are increasingly being linked. The aim of this study was to quantify serum levels of Gal-3, pro- and anti-inflammatory cytokines (including their ratios and correlations), and participant\'s condition (pain, stiffness, functional limitations) in gonarthrosis patients with and without diabetes mellitus.
A between-subject, cross-sectional experimental design was adopted. Serum levels of TNF-α, IL-6, IL-12, IL-23, IFN-γ, IL-17, IL-10, Gal-3, and WOMAC score were measured.
Gonarthrosis patients with diabetes mellitus had significantly (p < 0.05) lower levels of TNF-α, IL-6, IL-12, IL-17, IFN-γ, and Gal-3 compared to gonarthrosis patients without diabetes mellitus. On the other hand, IL-10/TNF-α, IL-10/IL-6, IL-10/IL-12, Gal-3/TNF-α, Gal-3/IL-6, and Gal-3/IL-12 (p = 0.001) were significantly higher (p < 0.05) in gonarthrosis with diabetes mellitus. Moderate-large correlation (p < 0.05) was detected between the serum values of Gal-3 and pro- and anti-inflammatory cytokines, including IL-12 (r = 0.575), IL-10 (r = 0.535), TNF-α (r = 0.306), and IL-23 (r = 0.323). WOMAC index was significantly lower (p < 0.05) in gonarthrosis patients without diabetes mellitus compared to gonarthrosis patients with diabetes mellitus.
Correlation between Gal-3 and proinflammatory cytokines and its dominance over proinflammatory cytokines implicate the potential role of Gal-3 in preventing cartilage destruction.
A between-subject, cross-sectional experimental design was adopted. Serum levels of TNF-α, IL-6, IL-12, IL-23, IFN-γ, IL-17, IL-10, Gal-3, and WOMAC score were measured.
Gonarthrosis patients with diabetes mellitus had significantly (p < 0.05) lower levels of TNF-α, IL-6, IL-12, IL-17, IFN-γ, and Gal-3 compared to gonarthrosis patients without diabetes mellitus. On the other hand, IL-10/TNF-α, IL-10/IL-6, IL-10/IL-12, Gal-3/TNF-α, Gal-3/IL-6, and Gal-3/IL-12 (p = 0.001) were significantly higher (p < 0.05) in gonarthrosis with diabetes mellitus. Moderate-large correlation (p < 0.05) was detected between the serum values of Gal-3 and pro- and anti-inflammatory cytokines, including IL-12 (r = 0.575), IL-10 (r = 0.535), TNF-α (r = 0.306), and IL-23 (r = 0.323). WOMAC index was significantly lower (p < 0.05) in gonarthrosis patients without diabetes mellitus compared to gonarthrosis patients with diabetes mellitus.
Correlation between Gal-3 and proinflammatory cytokines and its dominance over proinflammatory cytokines implicate the potential role of Gal-3 in preventing cartilage destruction.
摘要：
关节炎和糖尿病是两种越来越相关的疾病。这项研究的目的是量化Gal-3，促炎和抗炎细胞因子的血清水平（包括它们的比例和相关性），和参与者的状况(疼痛，刚度,功能限制）患有和不患有糖尿病的关节炎患者。
主题之间，采用横断面实验设计。血清TNF-α水平,IL-6，IL-12，IL-23，IFN-γ，测量IL-17、IL-10、Gal-3和WOMAC评分。
合并糖尿病的关节炎患者的TNF-α水平显著降低(p<0.05),IL-6，IL-12，IL-17，IFN-γ，和Gal-3与无糖尿病的膝关节病患者相比。另一方面,IL-10/TNF-α,IL-10/IL-6,IL-10/IL-12,Gal-3/TNF-α,Gal-3/IL-6和Gal-3/IL-12（p=0.001）在糖尿病性关节炎中明显更高（p<0.05）。检测到Gal-3与促炎和抗炎细胞因子的血清值之间存在中等大相关性（p<0.05），包括IL-12（r=0.575），IL-10（r=0.535），TNF-α（r=0.306），IL-23(r=0.323)。与糖尿病性关节炎患者相比，无糖尿病性关节炎患者的WOMAC指数显着降低（p<0.05）。
Gal-3与促炎细胞因子之间的相关性及其对促炎细胞因子的优势暗示了Gal-3在预防软骨破坏中的潜在作用。
主题之间，采用横断面实验设计。血清TNF-α水平,IL-6，IL-12，IL-23，IFN-γ，测量IL-17、IL-10、Gal-3和WOMAC评分。
合并糖尿病的关节炎患者的TNF-α水平显著降低(p<0.05),IL-6，IL-12，IL-17，IFN-γ，和Gal-3与无糖尿病的膝关节病患者相比。另一方面,IL-10/TNF-α,IL-10/IL-6,IL-10/IL-12,Gal-3/TNF-α,Gal-3/IL-6和Gal-3/IL-12（p=0.001）在糖尿病性关节炎中明显更高（p<0.05）。检测到Gal-3与促炎和抗炎细胞因子的血清值之间存在中等大相关性（p<0.05），包括IL-12（r=0.575），IL-10（r=0.535），TNF-α（r=0.306），IL-23(r=0.323)。与糖尿病性关节炎患者相比，无糖尿病性关节炎患者的WOMAC指数显着降低（p<0.05）。
Gal-3与促炎细胞因子之间的相关性及其对促炎细胞因子的优势暗示了Gal-3在预防软骨破坏中的潜在作用。
